INT182297

Context Info Confidence 0.42 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.36 Pain Relevance 1.53

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency chondrocytes 2 adipocytes 2 nervous system 2 MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 129 99.76 Osteoarthritis 138 98.80 Central nervous system 2 98.40 Inflammatory response 5 96.16 dexamethasone 43 90.80 rheumatoid arthritis 73 80.56 cytokine 44 79.00 medulla 44 76.00 Spinal cord 34 75.44 Pain 19 56.56

Disease Link Frequency Relevance Heat Obesity 68 99.98 Apoptosis 22 99.80 INFLAMMATION 133 99.76 Injury 17 99.52 Osteoarthritis 140 98.80 Synovitis 4 97.92 Stress 84 96.16 Parkinson's Disease 1 88.08 Arthritis 20 82.32 Rheumatoid Arthritis 73 80.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced phosphorylation of p38-MAPK was inhibited in chondrocytes pre-treated with PE (Figure 4a).

Positive_regulation (induced) of Phosphorylation (phosphorylation) of p38 in chondrocytes

1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.73 Pain Relevance 0.37

Figure 2 confirms that the action of LPS on mature adipocytes results in p38 protein phosphorylation with a peak obtained 5 minutes after stimulation.

Positive_regulation (results) of Phosphorylation (phosphorylation) of p38 in adipocytes associated with obesity

2) Confidence 0.31 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.10 Pain Relevance 0

ET-1 at 10 nM induced p38, Akt, p44/42, and SAP/JNK phosphorylation in a time-ordered manner.

Positive_regulation (induced) of Phosphorylation (phosphorylation) of p38

3) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.05 Pain Relevance 0

for 30 min significantly increased the phosphorylation state of JNK and p38 MAP kinases (Figure 6).

Positive_regulation (increased) of Phosphorylation (phosphorylation) of p38

4) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.08 Pain Relevance 0.57

To investigate the involvement of MAP kinase pathway in the inhibitory effect by melttin and bee venom on NO and PGE2 production, the activation of MAP kinase (phosphorylation of ERK, JNK and p38) induced by LPS and SNP was evaluated in both Raw 264.7 cells as well as synoviocytes.

Positive_regulation (activation) of Phosphorylation (phosphorylation) of p38

5) Confidence 0.08 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.08 Pain Relevance 0.04

Inflammatory signalling resulting in p38 phosphorylation has been identified as an important determinant of synovitis severity [49].

Positive_regulation (resulting) of Phosphorylation (phosphorylation) of p38 associated with inflammation and synovitis

6) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.97 Pain Relevance 0.37

Stretch injury has also been shown to induce phosphorylation of p38MAP kinase and apoptosis in vascular, heart and lung cells.[105] Clearly, the importance of biomechanical stresses upon the nervous system warrants closer attention.

Positive_regulation (induce) of Phosphorylation (phosphorylation) of p38MAP kinase in nervous system associated with stress, injury and apoptosis

7) Confidence 0.01 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC2940090 Disease Relevance 1.34 Pain Relevance 0.18

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