INT182317

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.63
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
cytotoxic T cells 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 201 99.44 Very High Very High Very High
Potency 1 77.64 Quite High
Inflammation 30 67.04 Quite High
Inflammatory stimuli 3 58.32 Quite High
cytokine 15 47.60 Quite Low
chemokine 3 46.48 Quite Low
Hippocampus 13 22.56 Low Low
long-term potentiation 3 18.00 Low Low
methotrexate 51 16.80 Low Low
Arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 118 100.00 Very High Very High Very High
Rheumatoid Arthritis 201 99.44 Very High Very High Very High
Pancreatic Cancer 95 98.90 Very High Very High Very High
Recurrence 21 96.38 Very High Very High Very High
Solid Tumor 3 94.04 High High
Targeted Disruption 1 86.64 High High
Arthropathy 96 86.60 High High
Breast Cancer 22 85.32 High High
Stress 6 84.40 Quite High
Disease 75 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The resulting offspring that were heterozygous for Cre and homozygous for floxed survivin (Survivinlox/lox) (hereafter referred to as SurvivinCamcre mice) were compared to littermate control mice which did not express Cre and were Survivinlox/lox.
survivin Binding (homozygous) of
1) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.39 Pain Relevance 0
Survivin is an ideal tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells [21].
Survivin Binding (recognized) of in cytotoxic T cells associated with cancer
2) Confidence 0.23 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.80 Pain Relevance 0.04
Survivin expression was not associated with p53 or Bax expression (p = 0.9969 and 0.0931, respectively, Table 4)

Survivin, p53, and bax expression and clinico-pathologic characteristics

Survivin Neg (not) Binding (associated) of
3) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.33 Pain Relevance 0
However, It is not determined that survivin may not be associated with poor clinical outcome because of limitation of our study.
survivin Binding (associated) of
4) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.59 Pain Relevance 0
It is important to predict recurrence or metastatic pattern after curative surgery because of determining adequate adjuvant treatment modality in pancreatic cancer, so further study may be warranted to investigate the association between survivin and pathological parameters.
survivin Binding (association) of associated with pancreatic cancer and recurrence
5) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.67 Pain Relevance 0
Interestingly, reactivity against survivin was significantly higher in the patient group with non-erosive RA.
survivin Binding (reactivity) of associated with rheumatoid arthritis
6) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.98 Pain Relevance 0.24
To determine whether survivin was independently associated with erosive RA, we developed a multivariate logistic regression model with radiological changes as the dependent variable and with RF, duration of RA, gender, and the survivin level as independent variables.
survivin Binding (associated) of associated with rheumatoid arthritis
7) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.87 Pain Relevance 0.28
Interaction with survivin transcription
survivin Binding (Interaction) of
8) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0 Pain Relevance 0

General Comments

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