INT182334

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 4.81
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Glrb) endoplasmic reticulum (Glrb) plasma membrane (Glrb)
Glrb (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 82 100.00 Very High Very High Very High
Crohn's disease 96 99.88 Very High Very High Very High
rheumatoid arthritis 106 99.30 Very High Very High Very High
Inflammation 128 95.76 Very High Very High Very High
Arthritis 104 82.52 Quite High
psoriasis 24 73.68 Quite High
member 8 8 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 82 100.00 Very High Very High Very High
Disease 290 99.88 Very High Very High Very High
Rheumatoid Arthritis 106 99.30 Very High Very High Very High
Hyperplasia 18 97.04 Very High Very High Very High
Disease Susceptibility 24 96.84 Very High Very High Very High
INFLAMMATION 82 95.76 Very High Very High Very High
Genetic Predisposition To Disease 8 92.64 High High
Synovitis 32 89.88 High High
Seronegative Spondarthritis 66 82.52 Quite High
Inflammatory Bowel Disease 64 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histopathological heterogeneity within SpA
SpA Binding (heterogeneity) of
1) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.60 Pain Relevance 0.29
Independently of these pathogenetic considerations, the present data also raise the question of the value of synovial histopathology as a biomarker in SpA.
SpA Binding (biomarker) of
2) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.18 Pain Relevance 0.20
The HLA-B27 allele is the first genetic factor which was demonstrated to be associated with AS [6],[7] and other SpA [4],[5],[8].
SpA Binding (associated) of associated with spinal inflammation
3) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 1.34 Pain Relevance 0.66
Indeed, no tag SNP association was identified in this region and none of the five SNPs described as associated with CD were associated with SpA in our analyses.
SpA Spec (analyses) Binding (associated) of associated with crohn's disease
4) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.26 Pain Relevance 0.09
All the markers significantly associated with SpA in all of our association studies belong to the same LD block (Figure 4).
SpA Binding (associated) of
5) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
These investigations led us to confirm the strong association with SpA of the whole LD block containing these SNPs (Figure 4).
SpA Binding (association) of
6) Confidence 0.16 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.08 Pain Relevance 0.04
First of all, the alleles of rs6478105 and rs10982396, which were found to be associated with SpA in the pooled case/control sample, were highly frequent (>0.89).
SpA Binding (associated) of
7) Confidence 0.14 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.13 Pain Relevance 0.03
Notably the TRAF1-C5 locus previously identified as associated with rheumatoid arthritis did not show any association with SpA in our investigation (Figure 2A).


SpA Binding (investigation) of associated with rheumatoid arthritis
8) Confidence 0.14 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.10 Pain Relevance 0.05
Using a stepwise linkage and association approach, we identified a haplotype spanning 6 single-nucleotide polymorphisms strongly associated with SpA and located in a genomic region paralogous to the MHC, near to the TNFSF15 gene.
SpA Binding (associated) of
9) Confidence 0.14 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2689651 Disease Relevance 0.76 Pain Relevance 0.26
We previously reported significant evidence of linkage of SpA to chromosome 9q31–34.
SpA Binding (linkage) of
10) Confidence 0.12 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2689651 Disease Relevance 0.28 Pain Relevance 0.05

General Comments

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