INT182367

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.99 Pain Relevance 0.11

cytosol (Vim) structural molecule activity (Vim) cytoskeleton (Vim) cytoplasm (Vim)

Anatomy Link Frequency chondrocyte 1 IgG (Mus musculus) Vim (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 21 81.60 methotrexate 6 64.72 Inflammation 25 49.48 chemokine 2 48.16 cytokine 5 47.56 Arthritis 15 5.00 Multiple sclerosis 3 5.00 Central nervous system 2 5.00 Inflammatory response 2 5.00 spinal inflammation 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 100.00 Viral Infection 10 84.20 Rheumatoid Arthritis 21 81.60 Autoimmune Disease 19 77.76 Enterovirus Infection 3 73.00 Targeted Disruption 3 65.04 Diabetes Mellitus 1 60.00 Bacterial Respiratory Disease 2 55.44 Infection 32 51.16 INFLAMMATION 26 49.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of interest are responses to the following: collagen type II, proteoglycans and chondrocyte glycoprotein 39; nuclear lamins, topoisomerase II and RA33 antigen (heterogeneous nuclear ribonucleoprotein A2); cytoplasmic antigens such as anti-neutrophil cytoplasmic antibodies; extracellular antigens such as keratin and IgG, the target of typical rheumatoid factors; and apoptosis-related proteins such as annexin V, calpastatin, vimentin and filaggrin [107-115].

IgG Regulation (target) of vimentin in chondrocyte associated with apoptosis

1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 0.99 Pain Relevance 0.11

General Comments

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