INT182419

Context Info Confidence 0.68 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 0.37 Pain Relevance 0

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1) hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)

OGG1 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 5 5.00 Pain 5 5.00 imagery 5 5.00

Disease Link Frequency Relevance Heat Cancer 45 92.40 Stress 5 48.80 Cockayne Syndrome 10 5.00 Pain 5 5.00 Disease 5 5.00 Aging 5 5.00 Adenoma 5 5.00 Contagious Ecthyma 5 5.00 Colon Cancer 5 5.00 Carcinoma 5 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, by mimicking a hOGG1 protein phosphorylated at Ser-326 we demonstrate that the regulation of the nucleolar localization, soluble chromatin, nuclear matrix and condensed chromatin association of hOGG1 are mediated through the phosphorylation of Ser-326.

Phosphorylation (phosphorylated) of hOGG1

1) Confidence 0.68 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0

Finally, we had identified a phosphorylated form of EGFP-hOGG1 in the chromatin fraction by western blotting using a phosphoserine-specific antibody (47).

Phosphorylation (phosphorylated) of EGFP-hOGG1

2) Confidence 0.68 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.08 Pain Relevance 0

Further studies are needed to elucidate the complete phosphorylation status of hOGG1 during the cell cycle.

Phosphorylation (phosphorylation) of hOGG1

3) Confidence 0.68 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.06 Pain Relevance 0

We investigated the cellular localization of the corresponding protein, hOGG1-Cys326, fused to EGFP and observed a dramatic effect on its localization that is explained by a change in the phosphorylation status of hOGG1.

Phosphorylation (phosphorylation) of hOGG1

4) Confidence 0.52 Published 2005 Journal Nucleic Acids Research Section Abstract Doc Link PMC1072800 Disease Relevance 0.15 Pain Relevance 0

Finally, we had identified a phosphorylated form of EGFP-hOGG1 in the chromatin fraction by western blotting using a phosphoserine-specific antibody (47).

Phosphorylation (form) of EGFP-hOGG1

5) Confidence 0.52 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.08 Pain Relevance 0

General Comments

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