INT182828

Context Info Confidence 0.16 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 0.67 Pain Relevance 0.55

HDDC3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 41 100.00 COX-2 inhibitor 4 87.80 Inflammation 30 79.28 palliative 74 50.00 cva 2 18.40 fibrosis 2 15.24 Acupuncture 22 5.00 tolerance 22 5.00 depression 9 5.00 Pain 8 5.00

Disease Link Frequency Relevance Heat Cancer 17 98.80 Polycystic Ovary Syndrome 6 92.52 Staphylococcus Infection 14 92.16 INFLAMMATION 32 79.28 Breast Disease 5 50.00 Disease 43 46.04 Reprotox - General 1 2 39.64 Amnesia 1 36.72 Cognitive Disorder 2 35.96 Nervous System Injury 1 34.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A Revised Master Search was devised incorporating the most frequently occurring MeSH terms.

Positive_regulation (occurring) of MeSH

1) Confidence 0.16 Published 2007 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC1931586 Disease Relevance 0 Pain Relevance 0

Although the six most frequently appearing MeSH terms did not actually have any subheadings, the analysis was undertaken using exact MeSH terms (with or without subheadings) as they appeared in the citations.

Positive_regulation (appearing) of MeSH

2) Confidence 0.16 Published 2007 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC1931586 Disease Relevance 0 Pain Relevance 0

strategy 2: (“cytokines” [MeSH

Positive_regulation (cytokines) of MeSH associated with cytokine

3) Confidence 0.07 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2324165 Disease Relevance 0.48 Pain Relevance 0.39

The complexity of the Boolean queries often leads to their execution failure after some minor changes in the medical databases (for example, updates of MeSH headings).

Positive_regulation (updates) of MeSH

4) Confidence 0.06 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2966450 Disease Relevance 0 Pain Relevance 0

All identified terms from a matching MeSH thesaurus entry were added to the initial query, which was then re-submitted to the search engine.12

Positive_regulation (matching) of MeSH

5) Confidence 0.06 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2966450 Disease Relevance 0.09 Pain Relevance 0

To test this hypothesis we searched Medline using the MeSH term "statins", "statins AND cancer (as well as other indications one by one)" for overall and yearwise extraction of citations.

Positive_regulation (using) of MeSH associated with cancer

6) Confidence 0.03 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 0.10 Pain Relevance 0.16

General Comments

This test has worked.