INT183002

Context Info Confidence 0.29 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.08 Pain Relevance 0

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA) enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)

RARA (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 4 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 40 99.98 Neuroblastoma 12 97.00 Repression 8 5.00 Pain 2 5.00 Apoptosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, RA stimulated the activity of the RAR?

Positive_regulation (stimulated) of RAR Binding (activity) of associated with rheumatoid arthritis

1) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.63 Pain Relevance 0

This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.

Positive_regulation (requirements) of RAR Binding (heterodimer) of associated with rheumatoid arthritis

2) Confidence 0.29 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0

General Comments

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