INT1834

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Context Info
Confidence 0.46
First Reported 1975
Last Reported 1975
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 2 100.00 Very High Very High Very High
Morphine 14 99.92 Very High Very High Very High
Dopamine 14 99.50 Very High Very High Very High
Analgesic 2 97.88 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analgesic doses of morphine and viminol R2 increase the turnover rate of dopamine (DA) in rat striatum but fail to increase the striatal concentration of adenosine 3',5'-monophosphate (cAMP) or the affinity of tyrosine hydroxylase (TH) for the pteridine cofactor.
Neg (fail) Positive_regulation (increase) of TH Binding (affinity) of in striatum associated with adenocard, dopamine, analgesic and morphine
1) Confidence 0.46 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 0.89
Similarly to morphine, haloperidol enhances the turnover rate of striatal DA, but unlike morphine it increases the affinity of TH for the pteridine cofactor and blocks the in vitro activation of striatal adenylacte cyclase by DA.
Positive_regulation (increases) of TH Binding (affinity) of associated with dopamine and morphine
2) Confidence 0.44 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 239224 Disease Relevance 0 Pain Relevance 1.01

General Comments

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