INT18345

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.99
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
plasma 12
eye 2
arcuate nucleus 2
thyroid 2
brain 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 5 100.00 Very High Very High Very High
Clonidine 14 99.98 Very High Very High Very High
Morphine 10 99.98 Very High Very High Very High
Serotonin 2 99.16 Very High Very High Very High
Somatostatin 9 98.88 Very High Very High Very High
rheumatoid arthritis 6 98.88 Very High Very High Very High
Enkephalin 17 98.76 Very High Very High Very High
Dopamine 3 98.72 Very High Very High Very High
Fibrositis 9 97.96 Very High Very High Very High
noradrenaline 3 94.48 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 20 100.00 Very High Very High Very High
Rheumatoid Arthritis 6 98.88 Very High Very High Very High
Sprains And Strains 6 98.68 Very High Very High Very High
Congenital Anomalies 6 98.42 Very High Very High Very High
Stress 24 98.06 Very High Very High Very High
Fibromyalgia 6 97.96 Very High Very High Very High
Adrenocortical Hyperfunction 2 96.92 Very High Very High Very High
Hypoglycemia 1 95.80 Very High Very High Very High
Xerostomia 1 95.20 Very High Very High Very High
Sleep Disorders 1 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the 'blood-brain barrier', and that the norepinephrine acts via alpha-adrenergic receptors.
Positive_regulation (mediated) of Positive_regulation (increase) of growth hormone in brain associated with dopamine
1) Confidence 0.42 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.28
The stress-induced inhibition of growth hormone was observed in Long Evans rats only, whereas the morphine stimulated plasma growth hormone increase was observed in animals of both strains.
Positive_regulation (stimulated) of Positive_regulation (increase) of growth hormone in plasma associated with stress, sprains and strains and morphine
2) Confidence 0.39 Published 1984 Journal Endocrinol. Exp. Section Abstract Doc Link 6335081 Disease Relevance 0.79 Pain Relevance 0.50
Clonidine potentiates the growth hormone (GH) response to GH-releasing hormone in norepinephrine synthesis-inhibited rats: evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin.
Positive_regulation (potentiates) of Positive_regulation (response) of growth hormone associated with somatostatin and clonidine
3) Confidence 0.37 Published 1993 Journal Neuroendocrinology Section Title Doc Link 7901787 Disease Relevance 0 Pain Relevance 0.42
The data suggest that collagen accumulation in diabetic myocardium does not appear to be dependent on increased plasma levels of growth hormone, but a role for enhanced sensitivity to hormonal action is not excluded.
Positive_regulation (dependent) of Positive_regulation (increased) of growth hormone in plasma associated with diabetes mellitus
4) Confidence 0.33 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3611950 Disease Relevance 0.58 Pain Relevance 0.24
A Met5-enkephalin analog, FK33-824 (5, 10 and 20 micrograms/100 g body wt, iv) caused a dose-related increase in plasma growth hormone (GH) in urethane-anesthetized male rats.
Positive_regulation (caused) of Positive_regulation (increase) of growth hormone in plasma associated with enkephalin
5) Confidence 0.29 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3917569 Disease Relevance 0 Pain Relevance 0.28
Based upon measurements of urinary corticoids and a review of the literature it is suggested that the lack of a growth hormone response to stimulation was due to the enhanced release of somatostatin as a result of mild and fluctuating hyperadrenocorticism.
Positive_regulation (due) of Positive_regulation (response) of growth hormone associated with somatostatin and adrenocortical hyperfunction
6) Confidence 0.27 Published 1993 Journal Vet. Rec. Section Abstract Doc Link 8116157 Disease Relevance 0.28 Pain Relevance 0.12
Stimulation with clonidine and growth hormone releasing hormone (GHRH) before and after repeated injections of GHRH did not result in significant increases in growth hormone concentrations in plasma.
Neg (not) Positive_regulation (result) of Positive_regulation (increases) of growth hormone in plasma associated with clonidine
7) Confidence 0.27 Published 1993 Journal Vet. Rec. Section Abstract Doc Link 8116157 Disease Relevance 0.30 Pain Relevance 0.10
Growth hormone-releasing hormone and morphine attenuate growth hormone secretagogue-induced activation of the arcuate nucleus in the male rat.
Positive_regulation (secretagogue-induced) of Positive_regulation (activation) of growth hormone in arcuate nucleus associated with morphine
8) Confidence 0.25 Published 1999 Journal Neuroendocrinology Section Title Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.31
In the pituitary, haloperidol and sulpiride induced similar increases of mRNAs of pro-opiomelanocortin (POMC) (+65% and +73%), prolactin (PRL) (+821% and +840%) and growth hormone (GH) (+32% and +47%), but sulpiride induced a greater increase of D2R mRNA (+125%) than haloperidol (+92%).
Positive_regulation (induced) of Positive_regulation (increases) of growth hormone in pituitary
9) Confidence 0.22 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.20
The data suggest that collagen accumulation in diabetic myocardium does not appear to be dependent on increased plasma levels of growth hormone, but a role for enhanced sensitivity to hormonal action is not excluded.
Positive_regulation (dependent) of Positive_regulation (accumulation) of growth hormone in plasma associated with diabetes mellitus
10) Confidence 0.22 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3611950 Disease Relevance 0.65 Pain Relevance 0.25
A single dose of 0.5 micrograms beta-endorphin injected intraventricularly in unanesthetized male rats bearing chronic intraventricular and intrajugular cannulas led to a sevenfold stimulation of plasma prolactin (PRL) levels 10 to 20 min after injection of the peptide, while a dose of 2 micrograms of beta-endorphin led to a comparable stimulation of plasma growth hormone (GH) concentration.
Positive_regulation (led) of Positive_regulation (stimulation) of growth hormone in plasma
11) Confidence 0.12 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 7380027 Disease Relevance 0.06 Pain Relevance 0.52
Twenty patients with fibromyalgia syndrome and 20 patients with rheumatoid arthritis (RA) were assessed as outpatients over a 3 day period with respect to peak and trough levels of plasma cortisol, growth hormone, prolactin, ACTH and thyroid stimulating hormone.
Positive_regulation (respect) of Positive_regulation (levels) of growth hormone in thyroid associated with rheumatoid arthritis and fibrositis
12) Confidence 0.05 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2607509 Disease Relevance 0.88 Pain Relevance 0.48
Increase in growth hormone and catecholamine levels mediates the acute effects on neutrophils whereas cortisol exerts its effects within a time lag of at least 2?
Positive_regulation (mediates) of Positive_regulation (Increase) of growth hormone in neutrophils associated with catecholamine
13) Confidence 0.04 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442120 Disease Relevance 0.29 Pain Relevance 0.14
The mean peak hGH response to an intravenous bolus of growth hormone releasing hormone was intermediate for the GHND group compared to hGH deficient and control groups.
Positive_regulation (intermediate) of Positive_regulation (response) of growth hormone
14) Confidence 0.04 Published 1987 Journal Acta Paediatr Scand Suppl Section Abstract Doc Link 3124498 Disease Relevance 0.10 Pain Relevance 0.10
Both 443C81 and dipipanone increased circulating prolactin and growth hormone and reduced cortisol levels.
Positive_regulation (increased) of Positive_regulation (circulating) of growth hormone
15) Confidence 0.03 Published 1990 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 1971216 Disease Relevance 0.28 Pain Relevance 0.82
Thus, both affective and schizoaffective patients but not schizophrenics, manifest abnormalities such as decreased platelet serotonin (5-HT) uptake, blunted clonidine-induced increase in serum growth hormone, shortened latency of rapid eye movement (REM) sleep, and increased REM density.
Positive_regulation (increased) of Positive_regulation (increase) of serum growth hormone in eye associated with congenital anomalies, serotonin and clonidine
16) Confidence 0.01 Published 1984 Journal Schizophr Bull Section Abstract Doc Link 6422546 Disease Relevance 0.78 Pain Relevance 0.15

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