INT183852

Context Info Confidence 0.41 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.63 Pain Relevance 0

intracellular (CAV1, RHOC) cytoplasm (CAV1, RHOC) cytosol (CAV1, RHOC) plasma membrane (CAV1, RHOC) endosome (CAV1) mitochondrion (CAV1)

Anatomy Link Frequency arm 2 CAV1 (Homo sapiens) RHOC (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 4 5.00 Inflammation 4 5.00 fibrosis 2 5.00

Disease Link Frequency Relevance Heat Adenocarcinoma 102 96.96 Cancer 62 86.96 Pancreatic Cancer 14 57.88 Clostridium Infection 2 55.36 Metastasis 46 49.24 Carcinoma 2 9.84 Pancreatitis 4 5.00 Inflammatory Breast Neoplasms 4 5.00 Renal Cancer 2 5.00 Pressure And Volume Under Development 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data further suggest that activation of RhoC GTPase is regulated by cav-1 and that RhoC signals through the p38 arm of the MAPK pathway to induce cellular migration.

cav-1 Regulation (regulated) of Positive_regulation (activation) of RhoC in arm

1) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.37 Pain Relevance 0

Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.

cav-1 Regulation (regulation) of Positive_regulation (activation) of RhoC

2) Confidence 0.25 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0

General Comments

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