INT184049

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg2b)
Anatomy Link Frequency
joint 2
Ighg2b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 100.00 Very High Very High Very High
rheumatoid arthritis 10 99.50 Very High Very High Very High
Inflammation 38 96.08 Very High Very High Very High
fibrosis 2 83.76 Quite High
Arthritis 4 74.96 Quite High
cINOD 1 64.88 Quite High
Crohn's disease 1 47.44 Quite Low
agonist 20 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 1 99.88 Very High Very High Very High
Rheumatoid Arthritis 10 99.50 Very High Very High Very High
INFLAMMATION 35 96.08 Very High Very High Very High
Adenoma 1 94.72 High High
Disease 20 91.88 High High
Fibrosis 1 83.76 Quite High
Hyperplasia 1 81.96 Quite High
Experimental Arthritis 1 74.96 Quite High
Synovitis 1 64.08 Quite High
Toxicity 1 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?
Positive_regulation (-) of Gene_expression (antibody) of IgG2c
1) Confidence 0.40 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0
The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?
Positive_regulation (control) of Gene_expression (antibody) of IgG2c
2) Confidence 0.40 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0
A mouse line of mutated gp130 in which the SHP-2/SOCS3-binding site was disrupted developed a RA-like joint disease with increased production of Th1-type cytokines and immunoglobulins of the IgG2a and IgG2b classes [78].
Positive_regulation (increased) of Gene_expression (production) of IgG2b in joint associated with rheumatoid arthritis, arthropathy and cytokine
3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.43 Pain Relevance 0.53

General Comments

This test has worked.

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