INT184102

Context Info Confidence 0.14 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.07

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo) plasma membrane (Cish)

Cish (Mus musculus) Thpo (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 50 92.96 Inflammation 34 50.16 rheumatoid arthritis 10 5.00 Arthritis 4 5.00 fibrosis 2 5.00 cerebral cortex 1 5.00 cINOD 1 5.00 tolerance 1 5.00 Crohn's disease 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 11 85.60 Syndrome 1 81.04 Lymphopenia 1 78.40 Hepatotoxicity 1 72.80 Disease 20 66.16 Non-genital Cutaneous Warts 1 58.24 INFLAMMATION 31 50.16 Cancer 13 5.00 Rheumatoid Arthritis 10 5.00 Hepatocellular Cancer 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, we have preliminary data suggesting that CIS is an important negative regulator of hematopoietic growth factors, including erythro-poietin, IL-3 and thrombopoietin (A Yoshimura, unpublished data).

CIS Negative_regulation (regulator) of thrombopoietin

1) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.62 Pain Relevance 0.07

General Comments

This test has worked.