INT184380

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.85
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fcgrt)
Anatomy Link Frequency
lumen 1
vesicle 1
Fcgrt (Mus musculus)
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 76.20 Quite High
rheumatoid arthritis 66 68.92 Quite High
Arthritis 80 64.12 Quite High
Inflammatory response 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 90.88 High High
Hypergammaglobulinemia 2 90.64 High High
Autoimmune Disease 18 76.96 Quite High
INFLAMMATION 67 76.20 Quite High
Peritonitis 2 73.12 Quite High
Arthus Reaction 16 72.16 Quite High
Rheumatoid Arthritis 66 68.92 Quite High
Arthritis 84 64.12 Quite High
Idiopathic Thrombocytopenic Purpura 2 56.56 Quite High
Hypersensitivity 65 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared to IgG acquired via intravenous injection, it is possible that ingested IgG selected by FcRn for absorption from the gut lumen has a higher binding affinity for FcRn systemically, and thereby has increased protection from catabolism.
FcRn Binding (affinity) of IgG in lumen
1) Confidence 0.27 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0 Pain Relevance 0
IgG not bound to the FcRn is transferred to lysosomes for degradation [45].
FcRn Binding (bound) of IgG
2) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.88 Pain Relevance 0.15
The FcRn binds pinocytosed IgG only in the acidic environment of the endosome and releases intact IgG when its transport vesicle is redirected to the neutral pH of the cell surface.
FcRn Binding (binds) of IgG in vesicle
3) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.97 Pain Relevance 0.22

General Comments

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