INT184431

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.94
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
articular 1
neurons 1
synovium 1
nasal cartilage 1
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 98.80 Very High Very High Very High
Pain 38 95.84 Very High Very High Very High
cytokine 32 94.60 High High
metalloproteinase 87 90.80 High High
Central nervous system 10 88.60 High High
Arthritis 40 86.40 High High
Osteoarthritis 55 57.08 Quite High
Hippocampus 6 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
Deafferentation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 122 99.76 Very High Very High Very High
INFLAMMATION 15 98.80 Very High Very High Very High
Necrosis 12 98.44 Very High Very High Very High
Tendinopathy 20 96.36 Very High Very High Very High
Adenocarcinoma 5 90.80 High High
Metastasis 6 90.32 High High
Prostate Cancer 25 87.00 High High
Arthritis 56 86.40 High High
Alzheimer's Dementia 5 85.44 High High
Rupture 8 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the involvement of ADAMTS1 in tumor progression is complex, with data also describing ADAMTS1 as a tumor promoting factor [4-6].
Transcription (describing) of ADAMTS1 associated with cancer
1) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.21 Pain Relevance 0.10
This increase was preceded by elevated ADAMTS1 and ADAMTS4 mRNA expression in dentate granule neurons [16].
Transcription (expression) of ADAMTS1 in neurons
2) Confidence 0.48 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.08 Pain Relevance 0.20
However, studies in human articular cartilage and bovine nasal cartilage and synovium suggest that the expression of ADAMTS-4 and -5 mRNA is relatively insensitive to retinoic acid or IL-1?
Transcription (expression) of ADAMTS in nasal cartilage
3) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.37 Pain Relevance 0.17
ADAMTS-1, -6 and -9 mRNA levels are upregulated in response to tumour necrosis factor-?
Transcription (levels) of ADAMTS-1 associated with necrosis and cancer
4) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.86 Pain Relevance 0.16
An upregulation of ADAMTS-4 mRNA expression has also been reported in an in vitro model of angiogenesis [40].
Transcription (expression) of ADAMTS
5) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.59 Pain Relevance 0.16
in retinal pigment epithelium-derived cells [68] and ADAMTS-4 mRNA expression is increased by IL-17 in articular chondrocytes [69], indicating that other ADAMTS proteins might also be upregulated by inflammatory cytokines.
Transcription (expression) of ADAMTS in articular associated with inflammation and cytokine
6) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.86 Pain Relevance 0.18
However, studies in human articular cartilage and bovine nasal cartilage and synovium suggest that the expression of ADAMTS-4 and -5 mRNA is relatively insensitive to retinoic acid or IL-1?
Transcription (expression) of ADAMTS in synovium
7) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.37 Pain Relevance 0.17
The values obtained for ADAMTS mRNA expression were normalised for GAPDH mRNA or 18S rRNA expression in the same sample, using the formulaADAMTS/(normalisingRNA)=2[Ct(normalisingRNA)?
Transcription (expression) of ADAMTS
8) Confidence 0.05 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
None of the ADAMTS mRNA expression showed a significant variation with age in this study (data not shown).


Transcription (expression) of ADAMTS
9) Confidence 0.05 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.61 Pain Relevance 0.17

General Comments

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