INT18456

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neurons 4
spinal 2
plasma 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 29 100.00 Very High Very High Very High
Central grey 8 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
midbrain 2 98.24 Very High Very High Very High
Paracetamol 7 98.02 Very High Very High Very High
Calcitonin gene-related peptide 5 95.28 Very High Very High Very High
Antinociceptive 2 95.28 Very High Very High Very High
Nerve growth factor 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 100.00 Very High Very High Very High
Fistula 1 98.12 Very High Very High Very High
Pain 1 94.60 High High
Neuropathic Pain 4 75.00 Quite High
Nociception 3 32.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative to the distribution of serotonin, somatostatin, peptide histidine isoleucine (PHI), methionine enkephalin, substance P and neurotensin-containing neuronal perikarya in the PAG, neurons containing immunoreactive pYT 22 occupied a unique location in the ventrolateral PAG.
Positive_regulation (occupied) of Transcription (distribution) of somatostatin in neurons associated with somatostatin, enkephalin, central grey, serotonin and substance p
1) Confidence 0.49 Published 1988 Journal Brain Res. Section Abstract Doc Link 3147123 Disease Relevance 0.69 Pain Relevance 0.74
Fifteen minutes after injection of urethane, somatostatin messenger RNA concentrations were increased by 128% compared with those in nontreated rats.
Positive_regulation (increased) of Transcription (concentrations) of somatostatin associated with somatostatin
2) Confidence 0.46 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.10 Pain Relevance 0.50
The same treatment increased somatostatin mRNA and immunostaining intensity of somatostatin neurons, but had no effect on the number of these labeled neurons.
Positive_regulation (increased) of Transcription (intensity) of somatostatin in neurons associated with somatostatin
3) Confidence 0.31 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.75
The cisplatin treatment significantly increased plasma somatostatin immunoreactivity and the expression of SSTR4 receptor detected both on the 11th and 22nd post-treatment days with no change in either CGRP, NK1, and NK2 receptor gene expression or plasma CGRP and substance P levels.
Positive_regulation (increased) of Transcription (immunoreactivity) of somatostatin in plasma associated with somatostatin, substance p and calcitonin gene-related peptide
4) Confidence 0.25 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.20 Pain Relevance 0.70
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of Transcription (transcript) of sst3R in spinal associated with paracetamol and somatostatin
5) Confidence 0.02 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 1.08

General Comments

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