INT184720

Context Info Confidence 0.55 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 5.23 Pain Relevance 1.10

transport (Smad3) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)

Anatomy Link Frequency macrophages 1 fibroblasts 1 keratinocytes 1 neutrophils 1 Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 62 92.24 antagonist 5 89.08 Osteoarthritis 91 84.24 Inflammation 126 38.40 cytokine 45 34.48 Inflammatory response 25 5.00 anesthesia 7 5.00 Inflammatory stimuli 5 5.00 Inflammatory mediators 5 5.00 metalloproteinase 3 5.00

Disease Link Frequency Relevance Heat Repression 14 100.00 Soft Tissue Injuries 5 99.52 Targeted Disruption 209 96.64 Injury 64 94.12 Pulmonary Fibrosis 40 92.24 Fibrosis 47 86.84 Aging 13 86.16 Osteoarthritis 96 84.24 Lung Injury 55 81.12 Adult Respiratory Distress Syndrome 10 72.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?

Negative_regulation (loss) of Smad3 in macrophages

1) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20

Together, these data suggest that, although it is not required for binding to Smad3, the N-terminus of Sox17 is important for repression of Smad3 transcriptional activity.

Negative_regulation (repression) of Smad3 associated with repression

2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.31 Pain Relevance 0

Inhibition of Smad3, or even partial reduction in its activity might afford protection against the toxicities of irradiation.

Negative_regulation (Inhibition) of Smad3

3) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.75 Pain Relevance 0.13

Since Sox17 negatively regulated Smad3 transcriptional activity in reporter assays but did not influence Smad3 nuclear import, we sought to determine if the repression was mediated by influencing Smad3 DNA binding.

Negative_regulation (regulated) of Smad3 associated with repression

4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.32 Pain Relevance 0

Interaction of Runx2 with Smad1 facilitates the function of Runx2 in stimulating terminal differentiation, while Smad3 blocks Runx2 function [81-83].

Negative_regulation (blocks) of Smad3

5) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.59 Pain Relevance 0.16

This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?

Negative_regulation (loss) of Smad3 in fibroblasts

6) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20

This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?

Negative_regulation (loss) of Smad3 in neutrophils

7) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20

This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?

Negative_regulation (loss) of Smad3 in keratinocytes

8) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20

General Comments

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