INT18480

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.18
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
Anatomy Link Frequency
blood 1
node 1
CSF 1
Blast cells 1
sperm 1
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 4 100.00 Very High Very High Very High
Opioid 6 97.88 Very High Very High Very High
vincristine 1 94.52 High High
Pain 7 93.96 High High
Angina 1 93.68 High High
Enkephalin 9 87.92 High High
Central nervous system 1 87.12 High High
backache 1 86.16 High High
Dynorphin 2 84.56 Quite High
cINOD 1 83.96 Quite High
Disease Link Frequency Relevance Heat
Pain 8 100.00 Very High Very High Very High
Pleural Effusion 3 99.88 Very High Very High Very High
Appetite Loss 8 99.58 Very High Very High Very High
Metastasis 27 99.04 Very High Very High Very High
Splenomegaly 4 97.88 Very High Very High Very High
Asthenozoospermia 2 97.72 Very High Very High Very High
Myeloid Leukemia 7 96.72 Very High Very High Very High
Pancreatic Cancer 12 96.30 Very High Very High Very High
Congenital Anomalies 2 95.64 Very High Very High Very High
Hyperplasia 2 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APN activity in the group of patients with chronic pain was significantly increased compared with that in group of healthy volunteers (4.25 +/- 0.17, n = 36 vs 3.53 +/- 0.21, n = 24, nmol.min-1.10(6) cells, P > 0.05, mean +/- SE).
Positive_regulation (increased) of APN associated with lasting pain
1) Confidence 0.59 Published 1998 Journal Masui Section Abstract Doc Link 9513326 Disease Relevance 0.53 Pain Relevance 0.81
These data are consistent with a significant role for aminopeptidase M activity in the degradation of low molecular weight opioid peptides in human CSF.
Positive_regulation (role) of aminopeptidase M in CSF associated with opioid
2) Confidence 0.55 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 1974424 Disease Relevance 0 Pain Relevance 0.60
High levels of activity of aminopeptidase N were found in the soluble and particulate sperm fractions of semen from patients presenting asthenozoospermia with necrozoospermia.
Positive_regulation (activity) of aminopeptidase N in sperm associated with asthenozoospermia
3) Confidence 0.44 Published 2004 Journal J. Androl. Section Abstract Doc Link 15292103 Disease Relevance 0.29 Pain Relevance 0.32
Sixty five ambulant pts with histologically proven APC had been screened between January 2002 and January 2004 in our university outpatient clinic in Berlin/Germany. 32 of them suffered from marked progressive cachexia and were willing to receive APN.
Positive_regulation (receive) of APN associated with appetite loss and pancreatic cancer
4) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841666 Disease Relevance 0.28 Pain Relevance 0
Splenomegaly recurred after cessation of the chemotherapy, and examination of the peripheral blood showed 31% blasts, positive for both CD13 and CD33, on which basis myeloid blastic transformation was diagnosed.
Positive_regulation (positive) of CD13 in blood associated with splenomegaly
5) Confidence 0.32 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 1.07 Pain Relevance 0.13
The cells from pleural effusion were positive for CD7, CD13, CD33, CD41a, including CD33, CD41a-double positive cells in 57.5%.
Positive_regulation (positive) of CD13 associated with pleural effusion
6) Confidence 0.32 Published 1994 Journal Rinsho Ketsueki Section Abstract Doc Link 8139119 Disease Relevance 0.73 Pain Relevance 0.09
Blast cells were positive for CD7, CD13, CD33, CD34, and HLA-DR, and negative for CD56.
Positive_regulation (positive) of CD13 in Blast cells
7) Confidence 0.29 Published 2001 Journal Rinsho Ketsueki Section Abstract Doc Link 11579505 Disease Relevance 1.00 Pain Relevance 0.08
More importantly, there was no increase in CD13 reactivity in the node metastasis specimens.
Neg (no) Positive_regulation (increase) of CD13 in node associated with metastasis
8) Confidence 0.25 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.77 Pain Relevance 0
Circulating blasts were positive for CD4, CD7, CD25, CD13, CD33, CD34, and HLA-DR and partly positive for CD41 and CD36.
Positive_regulation (positive) of CD13
9) Confidence 0.22 Published 1995 Journal Rinsho Ketsueki Section Abstract Doc Link 8531333 Disease Relevance 0.51 Pain Relevance 0.08

General Comments

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