INT184858

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.46
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Anatomy Link Frequency
shell 4
caudate nucleus 2
striatum 2
amygdala 2
midbrain 2
Lmo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1684 100.00 Very High Very High Very High
midbrain 231 100.00 Very High Very High Very High
Nucleus accumbens 198 99.66 Very High Very High Very High
Neurotransmitter 98 98.04 Very High Very High Very High
Glutamate 222 95.96 Very High Very High Very High
Hippocampus 44 94.04 High High
amygdala 44 93.40 High High
antagonist 101 93.24 High High
dopamine receptor 6 92.40 High High
imagery 22 91.92 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 451 99.92 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1793 99.20 Very High Very High Very High
Stress 55 95.16 Very High Very High Very High
Hypertension 77 92.56 High High
Urological Neuroanatomy 22 92.04 High High
Congenital Anomalies 26 88.64 High High
Sprains And Strains 33 78.68 Quite High
Depression 15 72.08 Quite High
Cognitive Disorder 99 56.72 Quite High
Obsessive-compulsive Disorder 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that increased expression of the DAT1 gene may reflect an attempt to compensate for increased tonic extracellular dopamine in the nucleus accumbens shell of SHR or increased DAT1 expression may occur in an attempt to compensate for decreased function of DAT1 in adult SHR striatum.
Positive_regulation (increased) of Gene_expression (expression) of DAT1 gene in shell associated with nucleus accumbens and dopamine
1) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.41 Pain Relevance 0.58
A possible disturbance in the regulation of the DAT1 gene is in agreement with findings that DAT1 gene expression is transiently reduced in SHR midbrain during the first postnatal month and increased in adult SHR compared to controls [50,51].
Positive_regulation (increased) of Gene_expression (expression) of DAT1 gene in midbrain associated with midbrain
2) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.61 Pain Relevance 0.28
These findings suggest that increased expression of the DAT1 gene may reflect an attempt to compensate for increased tonic extracellular dopamine in the nucleus accumbens shell of SHR or increased DAT1 expression may occur in an attempt to compensate for decreased function of DAT1 in adult SHR striatum.
Positive_regulation (increased) of Gene_expression (expression) of DAT1 in shell associated with nucleus accumbens and dopamine
3) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.57 Pain Relevance 0.49
In adults, increased expression of DAT1 might be expected to increase reuptake of dopamine, thereby reducing the need for synthesis by DOPA decarboxylase.
Positive_regulation (increased) of Gene_expression (expression) of DAT1 associated with dopamine
4) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.23 Pain Relevance 0.61
Although not every study found increased DAT [36,37], there is a strong possibility that the DAT1 gene is overexpressed in the striatum of ADHD subjects, and that this results in reduced synaptic dopamine.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of DAT1 gene in striatum associated with dopamine and attention deficit hyperactivity disorder
5) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.91 Pain Relevance 0.20
However, consistent with increased DAT1 expression in adult SHR striatum, extracellular dopamine levels are decreased in the caudate nucleus [55,56] and d-amphetamine-stimulated release of dopamine via DAT1 is greater in SHR striatum than WKY [54,57,58].
Positive_regulation (increased) of Gene_expression (expression) of DAT1 in caudate nucleus associated with dopamine
6) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.67
A likely explanation could also be that elevated extracellular dopamine levels could have resulted from decreased DAT1 expression during the first postnatal month of SHR [50] which caused compensatory upregulation of both DAT1 and DRD2 receptors [51,58,77].
Positive_regulation (resulted) of Gene_expression (expression) of DAT1 associated with dopamine
7) Confidence 0.17 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.64
Decreased expression of DAT1 will reduce reuptake and increase metabolism of dopamine.
Positive_regulation (increase) of Gene_expression (expression) of DAT1 associated with dopamine
8) Confidence 0.17 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.49 Pain Relevance 0.40
A likely explanation could also be that elevated extracellular dopamine levels could have resulted from decreased DAT1 expression during the first postnatal month of SHR [50] which caused compensatory upregulation of both DAT1 and DRD2 receptors [51,58,77].
Positive_regulation (caused) of Gene_expression (expression) of DAT1 associated with dopamine
9) Confidence 0.17 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.62
This deficiency could result from increased expression of DAT1, impaired dopamine synthesis, impaired release, or impaired regulation of extracellular dopamine by glutamate afferents from the prefrontal cortex, hippocampus, or amygdala [102].
Positive_regulation (increased) of Gene_expression (expression) of DAT1 in amygdala associated with glutamate, dopamine, hippocampus and amygdala
10) Confidence 0.15 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.16 Pain Relevance 0.97
These findings are consistent with increased expression of DAT1 increasing dopamine re-uptake and reutilization thereby reducing metabolism.
Positive_regulation (increased) of Gene_expression (expression) of DAT1 associated with dopamine
11) Confidence 0.15 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.17 Pain Relevance 0.81
In Korea, we investigated the differences of genotype distributions of the DAT1 gene between 115 OCD patients and 160 normal controls.70 Because a previous study showed that the 10-repeats allele is reported to increase DAT1 gene expression compared with the 7-, 9-, and 11-repeats alleles,71 we classified the genotype of DAT1 into 10/10-repeats and non-10/10-repeats groups.
Positive_regulation (increase) of Gene_expression (expression) of DAT1 gene associated with anxiety disorder
12) Confidence 0.12 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.69 Pain Relevance 0.19
Dopamine transporter gene (DAT1)
Positive_regulation (Dopamine transporter gene) of Gene_expression (Dopamine transporter gene) of DAT1 associated with dopamine
13) Confidence 0.08 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.76 Pain Relevance 0.57

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