INT184865

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.01
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Anatomy Link Frequency
shell 1
Lmo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 66 98.48 Very High Very High Very High
Nucleus accumbens 54 98.30 Very High Very High Very High
Dopamine 456 97.80 Very High Very High Very High
agonist 24 94.20 High High
antagonist 27 93.72 High High
cerebral cortex 12 89.72 High High
midbrain 63 51.64 Quite High
Locus ceruleus 39 41.64 Quite Low
Substantia nigra 21 37.76 Quite Low
Glutamate 60 14.28 Low Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 489 99.36 Very High Very High Very High
Hypertension 21 98.08 Very High Very High Very High
Targeted Disruption 9 87.32 High High
Ocular Toxicity (including Many Sub-types) 33 77.96 Quite High
Sprains And Strains 9 69.36 Quite High
Stress 15 35.04 Quite Low
Brain Disease 6 15.92 Low Low
Cognitive Disorder 27 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that psychostimulants reduce hyperactivity of 6-OHDA lesioned rats not by inhibiting DAT1 but by inhibiting norepinephrine and serotonin transporters.
Negative_regulation (inhibiting) of DAT1 associated with attention deficit hyperactivity disorder and serotonin
1) Confidence 0.14 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.76 Pain Relevance 0.35
Whereas specific inhibitors of NET1 or DAT1 did not affect DAT-KO hyperactivity, inhibitors of the SERT1 as well as drugs that activate the serotonergic system, such as serotonin receptor agonists and serotonin precursors, dramatically reduced hyperactivity [168].
Negative_regulation (inhibitors) of DAT1 associated with agonist, attention deficit hyperactivity disorder and serotonin
2) Confidence 0.14 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.70 Pain Relevance 0.54
These findings suggest that increased expression of the DAT1 gene may reflect an attempt to compensate for increased tonic extracellular dopamine in the nucleus accumbens shell of SHR or increased DAT1 expression may occur in an attempt to compensate for decreased function of DAT1 in adult SHR striatum.
Negative_regulation (decreased) of DAT1 in shell associated with nucleus accumbens and dopamine
3) Confidence 0.14 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.56 Pain Relevance 0.48

General Comments

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