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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 9.17
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 7
neuronal 4
dopaminergic neurons 4
dendrites 3
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 577 99.52 Very High Very High Very High
midbrain 88 98.80 Very High Very High Very High
Neurotransmitter 15 97.48 Very High Very High Very High
Spinal cord 64 90.44 High High
Serotonin 9 86.52 High High
monoamine 38 82.48 Quite High
dopaminergic neurodegeneration 25 79.92 Quite High
Inflammatory response 53 78.52 Quite High
Inflammation 237 69.68 Quite High
agonist 55 68.20 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 928 99.82 Very High Very High Very High
Hypertrophy 6 99.70 Very High Very High Very High
Lordosis 13 95.24 Very High Very High Very High
Toxicity 86 94.88 High High
Brain Tumor 2 92.24 High High
Death 99 91.76 High High
Urological Neuroanatomy 52 90.44 High High
Targeted Disruption 150 89.52 High High
Cancer 22 87.60 High High
Drug Induced Neurotoxicity 91 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced tyrosine hydroxylase expression in the FucM mutant
Negative_regulation (Reduced) of Gene_expression (expression) of tyrosine hydroxylase
1) Confidence 0.43 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.10 Pain Relevance 0
Nissl stain showed similar trends and statistical results (Fig. 1C &1D), suggesting an actual TH-positive neuronal loss instead of a loss of TH expression.
Negative_regulation (loss) of Gene_expression (expression) of TH in neuronal
2) Confidence 0.37 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.96 Pain Relevance 0
This implies that the lower TH count is due to degeneration of neurons rather than to reduction of TH expression.
Negative_regulation (reduction) of Gene_expression (expression) of TH in neurons
3) Confidence 0.37 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.86 Pain Relevance 0.07
Estimation of the total number of TH+ Nissl+ neurons using the Abercrombie correction, confirmed a dose-dependent reduction of TH+ Nissl+ neurons in MPTP-treated mice fed with control diet, suggesting an actual TH+ neuronal loss rather than loss of TH expression (Figure 4J).
Negative_regulation (loss) of Gene_expression (expression) of TH in neuronal associated with parkinson's disease
4) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.88 Pain Relevance 0
Thus, suggesting that there exists a percentage of dopaminergic neurons with decreased TH expression.
Negative_regulation (decreased) of Gene_expression (expression) of TH in dopaminergic neurons
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.24 Pain Relevance 0.08
Therefore in DAT-KO mice, acute TH inhibition alone by ?
Negative_regulation (Therefore) of Neg (inhibition) Gene_expression (inhibition) of TH
6) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.59
Our findings in ASKO mice demonstrated that a loss of a-Syn produced the opposite effect on TH and PP2A imply that enzymatic dysregulation can also occur by a loss of soluble a-Syn, as those mice express normal levels of ?
Negative_regulation (opposite) of Gene_expression (effect) of TH
7) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.12 Pain Relevance 0.06
Nissl staining showed similar trends and statistical results (Fig. 2C &2D), which indicates a true loss of the TH-positive neurons rather than a decrease in TH expression.
Negative_regulation (decrease) of Gene_expression (expression) of TH in neurons
8) Confidence 0.27 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.08 Pain Relevance 0.03
Importantly, in animals receiving 2R,4R-APDC post lesion, NeuN+ and TH+ cell loss was attenuated in parallel in the ipsilateral SNc, strongly supporting a neuroprotective effect, rather than alterations in TH expression in atrophic neurones.
Negative_regulation (supporting) of Gene_expression (expression) of TH
9) Confidence 0.25 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.20 Pain Relevance 0.16
Accordingly, we examined TH and DAT striatal expression using RT-PCR, immunohistochemistry coupled to confocal microscopy, and western blot (WB) analyses.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of TH
10) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.61 Pain Relevance 0.14
HCT1026 preventive administration decreases MPTP-induced loss of TH+ cell bodies in SNpc
Negative_regulation (loss) of Gene_expression (bodies) of TH associated with parkinson's disease
11) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.41 Pain Relevance 0.04
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Negative_regulation (loss) of Gene_expression (protein) of TH associated with parkinson's disease
12) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16
One other explanation for this loss of nigral dopaminergic neurons could be the down regulation of TH expression in the dopaminergic cells.
Negative_regulation (regulation) of Gene_expression (expression) of TH in dopaminergic neurons
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.48 Pain Relevance 0.14
Pten deletion leads to neuronal hypertrophy and increased number of TH positive neurons and dendrites in the ventral midbrain
Negative_regulation (number) of Gene_expression (neurons) of TH in dendrites associated with hypertrophy and midbrain
14) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.36 Pain Relevance 0.36
The concordance between the reduction of TH expression and neurodegeneration was made distinctive by the neuronal loss revealed by quantification of Nissl-stained neurons from adjacent sections caudal to the TH-stained sections.
Negative_regulation (reduction) of Gene_expression (expression) of TH in neurons
15) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.58 Pain Relevance 0.07
We assessed the expression of tyrosine hydroxylase (TH) and Nurr-1.
Negative_regulation (assessed) of Gene_expression (expression) of tyrosine hydroxylase
16) Confidence 0.20 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.07 Pain Relevance 0.10
We assessed the expression of tyrosine hydroxylase (TH) and Nurr-1.
Negative_regulation (assessed) of Gene_expression (expression) of TH
17) Confidence 0.20 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.07 Pain Relevance 0.10
Pten deletion leads to neuronal hypertrophy and increased number of TH positive neurons and dendrites in the ventral midbrain
Negative_regulation (number) of in neurons Gene_expression (neurons) of TH in dendrites associated with hypertrophy and midbrain
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.36 Pain Relevance 0.36

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