INT185152

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 14.93
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
T2dm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 71 91.24 High High
Inflammatory marker 4 80.16 Quite High
tolerance 28 79.92 Quite High
Inflammatory response 5 57.84 Quite High
cytokine 21 44.64 Quite Low
Angina 70 35.20 Quite Low
Hippocampus 10 16.64 Low Low
Bioavailability 8 10.00 Low Low
Osteoarthritis 34 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 555 100.00 Very High Very High Very High
Disease 149 99.96 Very High Very High Very High
Insulin Resistance 47 99.84 Very High Very High Very High
Obesity 228 99.52 Very High Very High Very High
Coronary Artery Disease 105 98.88 Very High Very High Very High
Weight Loss 9 98.64 Very High Very High Very High
Nicotine Addiction 39 97.16 Very High Very High Very High
Aging 40 96.64 Very High Very High Very High
Cancer 73 93.88 High High
Prediabetic State 4 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obese participants showed an increased probability of T2DM, when compared to participants in normal weight ranges.
Positive_regulation (increased) of T2DM associated with diabetes mellitus and obesity
1) Confidence 0.17 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2531108 Disease Relevance 1.95 Pain Relevance 0
In this cohort, 15.6% of the men examined at clinic, had T2DM by either self-report or fasting glucose or HbA1c, a figure slightly higher than the prevalence reported by the AusDiab study (12.3% of men aged over 35 years [48]).
Spec (examined) Positive_regulation (had) of T2DM associated with diabetes mellitus
2) Confidence 0.17 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2531108 Disease Relevance 1.26 Pain Relevance 0
Our results indicate that the eNOS pathway could be more important in women than in men regarding the T2DM-associated MI risk, and may offer part of an explanation for the higher risk increase observed when women get T2DM, compared to men [17,32].
Positive_regulation (increase) of T2DM associated with diabetes mellitus
3) Confidence 0.06 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.24 Pain Relevance 0
CRP was significantly increased in T2DM 8.2 (0.7–27.1) ?
Positive_regulation (increased) of T2DM associated with diabetes mellitus
4) Confidence 0.05 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1183229 Disease Relevance 0.91 Pain Relevance 0
Our previous studies have highlighted that serum resistin levels are increased in Caucasian T2DM subjects and reduced with modest weight loss [18,22] and these factors are also associated with changes in C-reactive protein (CRP) levels, CRP represents one of the acute phase proteins which increase during systemic inflammation.
Positive_regulation (increased) of T2DM associated with weight loss, inflammation and diabetes mellitus
5) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1183229 Disease Relevance 1.67 Pain Relevance 0.25
Therefore the aims of this study were to investigate for the first time whether serum resistin levels are increased in Saudi Arabians with T2DM and if this is affected by CHD.
Spec (whether) Positive_regulation (increased) of T2DM associated with coronary artery disease and diabetes mellitus
6) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1183229 Disease Relevance 1.67 Pain Relevance 0.07
For over 30 years, it has been known that fasting plasma glucagon levels are increased in T2DM and that glucagon secretion is not appropriately suppressed following a carbohydrate or mixed meal or may paradoxically increase.105–107 This abnormality is evident before the diagnosis of diabetes, and has been observed in subjects with IGT.108–110 Hyperglucagonemia in the fasting state results in excessive HGP and elevated FPG levels, while impaired suppression of plasma glucagon levels following a meal results in postprandial hyperglycemia.
Positive_regulation (increased) of T2DM in plasma associated with hyperglycemia and diabetes mellitus
7) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.62 Pain Relevance 0
Increases in T2DM are paralleled by a robust increase in people at high risk for the development of diabetes.
Positive_regulation (Increases) of T2DM associated with diabetes mellitus
8) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 1.11 Pain Relevance 0.08
Formerly considered an adult disease, T2DM has increased alarmingly among adolescents (Fagot-Campagna et al 2000).
Positive_regulation (increased) of T2DM associated with diabetes mellitus and disease
9) Confidence 0.01 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994001 Disease Relevance 2.25 Pain Relevance 0.06
T2DM is caused by insulin resistance in peripheral tissues and is most frequently associated with aging, a family history of diabetes, obesity and failure to exercise.
Positive_regulation (caused) of T2DM associated with aging, diabetes mellitus, obesity and insulin resistance
10) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 2.25 Pain Relevance 0

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