INT18520

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.63
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Adra2c, Ins1) extracellular space (Ins1) extracellular region (Ins1)
plasma membrane (Adra2c) carbohydrate metabolic process (Ins1) signal transducer activity (Adra2c)
Adra2c (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 16 99.96 Very High Very High Very High
antagonist 10 99.16 Very High Very High Very High
Clonidine 8 96.40 Very High Very High Very High
Catecholamine 4 78.32 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 10 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of glucose-evoked insulin release induced by the alpha-2 adrenoceptor agonists was concentration-dependently inhibited by the alpha-2 antagonists yohimbine, phentolamine, rauwolscine and idazoxan.
alpha-2 adrenoceptor Positive_regulation (induced) of Localization (release) of insulin associated with antagonist and agonist
1) Confidence 0.41 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1975625 Disease Relevance 0 Pain Relevance 0.62
However, neither the alpha-1 selective antagonist prazosin, nor the beta selective antagonist propranolol attenuated the inhibition of insulin release induced by alpha-2 adrenoceptor agonists.
alpha-2 adrenoceptor Positive_regulation (induced) of Localization (release) of insulin associated with antagonist and agonist
2) Confidence 0.30 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1975625 Disease Relevance 0 Pain Relevance 0.59
Pertussis vaccine, pertussis toxin, and the alpha-adrenoceptor blocking drug phentolamine augment glucose-induced insulin secretion.
alpha-adrenoceptor Positive_regulation (augment) of Localization (secretion) of insulin associated with bordatella infection
3) Confidence 0.17 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2898854 Disease Relevance 0.36 Pain Relevance 0.11
It is concluded that stimulation of insulin secretion by certain alpha-adrenoceptor blocking drugs can be dissociated from their alpha-adrenoceptor properties.
alpha-adrenoceptor Positive_regulation (stimulation) of Localization (secretion) of insulin
4) Confidence 0.17 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2898854 Disease Relevance 0.27 Pain Relevance 0.34

General Comments

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