INT18521

Context Info Confidence 0.71 First Reported 1984 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.46 Pain Relevance 1.56

mitochondrion (MAOB) small molecule metabolic process (MAOB) oxidoreductase activity (MAOB)

Anatomy Link Frequency neuron 1 sympathetic 1 MAOB (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 4 100.00 Cholecystokinin 1 100.00 Serotonin 1 100.00 Catechol-O-methyltransferase 9 98.64 qutenza 58 97.76 Pain 5 95.80 Somatostatin 1 89.60 Dopamine 1 88.04 medulla 5 75.00 nociceptor 2 67.60

Disease Link Frequency Relevance Heat Syndrome 1 96.76 Depression 1 93.60 Duodenal Ulcer 2 91.88 Cough 88 89.12 Disease 6 87.64 Chronic Fatigue Syndrome 40 86.36 Ulcers 1 75.00 Disease Susceptibility 5 54.24 General Immunology 2 52.52 Paralysis 8 25.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Normalization of adrenalin excretion served as an indicator of favourable prognosis.

Localization (excretion) of adrenalin

1) Confidence 0.71 Published 1990 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 1975712 Disease Relevance 0.53 Pain Relevance 0.10

As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.

Localization (releasing) of MAOB associated with catechol-o-methyltransferase

2) Confidence 0.28 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.49 Pain Relevance 0.13

In May 1904, in a preliminary communication to the Physiological Society, the young researcher made his—today famous—suggestion, that adrenalin was “secreted by the sympathetic paraganglia” and might be “the chemical stimulant liberated on each occasion when the [nervous] impulse arrives at the periphery”.60 While this proposal has placed Elliott firmly in the history of the concept of chemical neurotransmission,61 his thoughts on how the muscle cell received the stimulus of the “chemical excitant”, and reacted with a change of tension of the muscle fibres, were important for the development of the receptor idea.

Localization (secreted) of adrenalin in sympathetic

3) Confidence 0.07 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.05 Pain Relevance 0

These findings suggest the concomitant release of enkephalin and adrenalin by exocytosis.

Localization (release) of adrenalin associated with enkephalin

4) Confidence 0.04 Published 1984 Journal Histochemistry Section Abstract Doc Link 6373681 Disease Relevance 0 Pain Relevance 0.27

Additional data about correspondence of estradiol-target neuron accumulations with neuronal sites of peptide messenger production suggest direct effects of estradiol on certain enkephalin, endorphin, corticotropin releasing hormone, adrenalin, serotonin, cholecystokinin, pancreatic polypeptide and gonadotropin releasing hormone neurons--and probably others.

Localization (releasing) of adrenalin in neuron associated with enkephalin, cholecystokinin and serotonin

5) Confidence 0.02 Published 1984 Journal Peptides Section Abstract Doc Link 6384951 Disease Relevance 0 Pain Relevance 0.47

The intragastric administration of capsiate increases adrenalin secretion and oxygen consumption in mice [21,22].

Localization (secretion) of adrenalin

6) Confidence 0.01 Published 2007 Journal Cough Section Body Doc Link PMC2174508 Disease Relevance 0.39 Pain Relevance 0.61

General Comments

This test has worked.