INT185261

Context Info Confidence 0.65 First Reported 2005 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 9 Total Number 13 Disease Relevance 5.76 Pain Relevance 0.93

nucleolus (OLIG2) plasma membrane (OLIG2) nucleus (OLIG2) DNA binding (OLIG2) cytoplasm (OLIG2)

Anatomy Link Frequency motoneurons 4 nucleus 1 forebrain 1 oligodendrocyte 1 neural 1 OLIG2 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 10 95.36 Spinal cord 131 91.28 Dopamine 18 78.80 gABA 16 74.56 unmyelinated 1 70.56 Central nervous system 41 66.48 midbrain 10 59.12 Inflammation 1 34.24 anesthesia 6 26.52 Glutamate receptor 2 16.36

Disease Link Frequency Relevance Heat Oligodendroglioma 57 99.42 Rheumatoid Arthritis 54 99.24 Cancer 48 96.88 Vision Disorders 6 94.00 Retina Disease 9 92.52 Glioma 30 86.88 Spinal Cord Injury 145 86.16 Injury 88 71.28 Neuroepithelial Neoplasms 3 63.72 Contusions 9 58.64

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Event

Anatomy

Negation

Speculation

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Disease term

Nevertheless, OLIG2 is expressed in human OPC [45] and is necessary for specification and differentiation of human OPC [44].

Gene_expression (expressed) of OLIG2

1) Confidence 0.65 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.18 Pain Relevance 0.07

We determined that MP are able to mature and develop fundamental functions of normal motoneurons in vitro (expressing OLIG2, ISL1, and HOXC5), including directional growth of long axons, confirming the results from the previous study [11].

Gene_expression (expressing) of OLIG2 in motoneurons

2) Confidence 0.65 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.19 Pain Relevance 0.11

A ventralizing effect of RA was also observed by upregulation of OLIG2 expression, probably at the expense of IRX3, in agreement with previous findings suggesting that OLIG2 suppresses IRX3 [59] and interacts with progenitor homeodomain proteins, thus activating motor neuron differentiation pathway and HB9 gene.

Gene_expression (expression) of OLIG2 in motor neuron associated with rheumatoid arthritis

3) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.57 Pain Relevance 0.17

OLIGO-2 expression is relatively specific for oligodendrogliomas [8], and the combination of OLIGO-2 and GFAP expression provides further support for the diagnosis.

Gene_expression (expression) of OLIGO-2 associated with oligodendroglioma

4) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.48 Pain Relevance 0.05

OLIGO-2 expression is relatively specific for oligodendrogliomas [8], and the combination of OLIGO-2 and GFAP expression provides further support for the diagnosis.

Gene_expression (expression) of OLIGO-2 associated with oligodendroglioma

5) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.47 Pain Relevance 0.04

Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.

Gene_expression (expression) of Olig2

6) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03

Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.

Gene_expression (expression) of Olig2

7) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03

Analyzing the transcription phenotype of obtained OPC at day 42, we observed strong expression of OLIG2 [42–44], which gives rise to motoneurons during the neurogenic phase.

Gene_expression (expression) of OLIG2 in motoneurons

8) Confidence 0.56 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.19 Pain Relevance 0.04

To determine whether the neural progenitors have strictly rostral character we next examined the expression of caudal markers (Figures 4F and 4G) such as class I (IRX3, PAX6, PAX7) and class II (OLIG2, NKX2.2, NKX6.1), homeodomein proteins important for motoneuron differentiation [33], [34] and found them highly expressed at D7 and D42.

Spec (examined) Gene_expression (expression) of OLIG2 in motoneuron

9) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.23

The nucleus was positive for OLIGO-2 and the cytoplasm was positive for GFAP on immunohistochemical staining (Figure6, 7).

Gene_expression (positive) of OLIGO-2 in nucleus

10) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.46 Pain Relevance 0.05

All NS cells examined express the same panel of radial glia markers (Figures 5A and S2), plus the neural precursor markers Sox2, Sox3, and Emx2, and the bHLH (basic helix–loop helix) transcription factors Olig2 and Mash1 (Figure 5B).

Spec (examined) Gene_expression (express) of Olig2 in neural

11) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04

The presence of Olig2 and Mash1 is not characteristic of dorsal forebrain, and may reflect the ex vivo environment and a response to FGF-2.

Gene_expression (presence) of Olig2 in forebrain

12) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04

Approximately 31% of hCNS-SCns remained nestin positive suggesting that they remain undifferentiated, however of the cells that differentiated the majority differentiated along the oligodendrocyte lineage expressing the immature Olig2 marker or the mature APC-CC1 marker (41%) and nearly as many differentiated into ß-tubulin III-positive neurons (38%).

Gene_expression (expressing) of Olig2 in oligodendrocyte

13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923623 Disease Relevance 0.23 Pain Relevance 0.04

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