INT185379

Context Info Confidence 0.08 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.88 Pain Relevance 0.35

cytoplasm (IRF6, TLR2) cytosol (IRF6) signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2) nucleus (IRF6)

IRF6 (Homo sapiens) TLR2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 24 98.88 tolerance 3 97.36 Inflammatory mediators 3 95.80 rheumatoid arthritis 10 78.08 Inflammatory response 18 52.00 headache 4 48.12 cytokine 14 14.52 anesthesia 2 5.00 Infliximab 2 5.00 chemokine 2 5.00

Disease Link Frequency Relevance Heat Pseudomonas Infection 2 100.00 INFLAMMATION 47 98.88 Disease 84 89.56 Autoimmune Disease 2 85.20 Shock 4 79.24 Rheumatoid Arthritis 10 78.08 Injury 2 76.80 Systemic Lupus Erythematosus 1 74.40 Nicotine Addiction 67 72.44 Pneumococcal Infection 1 70.48

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Anatomy

Negation

Speculation

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LPS, isolated from Pseudomonas aeruginosa and E. coli, and LTA, isolated from Staphylococcus aureus, were purchased from Sigma (Sigma Aldrich, Singapore) and were used as ligands for TLR4 and TLR2/TLR6 at concentrations from 10 ng/ml to 10 ?

LPS Binding (ligands) of TLR2 associated with pseudomonas infection

1) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.10 Pain Relevance 0

TLR2 and TLR4 recognize lipoproteins and lipopolysaccharide (LPS), respectively.

LPS Binding (recognize) of TLR2

2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.69 Pain Relevance 0.21

Whole gram-negative bacteria are recognized not only through TLR4 (by LPS) but also TLR 2 (by bacterial lipopeptides).

LPS Binding (recognized) of TLR 2

3) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.79 Pain Relevance 0.05

However, LPS from some bacterial species, such as P. gingivalis, activate cells through TLR2 binding.

LPS Binding (binding) of TLR2

4) Confidence 0.01 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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