INT18538

From wiki-pain
Revision as of 18:28, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1980
Last Reported 2003
Negated 4
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.03
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 3
blood 2
hypothalamus 1
cell groups 1
medial 1
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Morphine 14 99.62 Very High Very High Very High
Dopamine 3 99.56 Very High Very High Very High
medulla 10 98.68 Very High Very High Very High
Clonidine 11 97.80 Very High Very High Very High
Rostroventromedial medulla 3 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 96.04 Very High Very High Very High
Hypertension 6 93.32 High High
Generalized Anxiety Disorder 2 93.24 High High
Hypertrophy 2 79.36 Quite High
Pheochromocytoma 1 75.52 Quite High
Urological Neuroanatomy 2 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged morphine treatment did not alter the PNMT activity in brain regions (A1/C1 and A2/C2 cell groups, medial basal hypothalamus, median eminence).
Neg (not) Regulation (alter) of PNMT in cell groups associated with morphine
1) Confidence 0.60 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2829923 Disease Relevance 0.08 Pain Relevance 0.58
Regulation of the putative peptide neurohumour [Leu]enkephalin and the catecholaminergic enzymes tyrosine hydroxylase and phenylethanolamine-N-methyl-transferase was examined in the rat adrenal medulla in vivo and in vitro.
Regulation (Regulation) of phenylethanolamine-N-methyl-transferase in adrenal medulla associated with medulla and enkephalin
2) Confidence 0.58 Published 1984 Journal Science Section Abstract Doc Link 6144183 Disease Relevance 0 Pain Relevance 0.61
The developmental expression of neuropeptide Y (NPY) and leucine-enkephalin (L-Enk) was examined in embryonic, early postnatal, and adult chromaffin cells with double- and triple-label immunocytochemical techniques and compared to the expression of immunoreactivity for tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT).
Regulation (immunoreactivity) of PNMT in chromaffin cells associated with neuropeptide and enkephalin
3) Confidence 0.44 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1975838 Disease Relevance 0 Pain Relevance 0.22
Effects of PNMT inhibitors on growth hormone (GH) secretion caused by clonidine were examined in order to assess the effects of PNMT inhibitors on postsynaptic alpha-2-adrenoceptors in the hypothalamus.
Regulation (Effects) of PNMT in hypothalamus associated with clonidine
4) Confidence 0.44 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.16
The effects of a centrally acting phenylethanolamine N-methyl-transferase (PNMT) inhibitor, SKF 64139, and of its analog, SKF 72223, which is devoid of PNMT inhibitory activity on blood pressure and heart rate, were investigated in spontaneously hypertensive rats (SHR) and in DOCA-salt hypertensive rats.
Spec (investigated) Regulation (effects) of PNMT in blood associated with hypertension
5) Confidence 0.44 Published 1982 Journal Life Sci. Section Abstract Doc Link 6125862 Disease Relevance 0.33 Pain Relevance 0
The developmental expression of neuropeptide Y (NPY) and leucine-enkephalin (L-Enk) was examined in embryonic, early postnatal, and adult chromaffin cells with double- and triple-label immunocytochemical techniques and compared to the expression of immunoreactivity for tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT).
Regulation (immunoreactivity) of phenylethanolamine N-methyltransferase in chromaffin cells associated with neuropeptide and enkephalin
6) Confidence 0.39 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1975838 Disease Relevance 0 Pain Relevance 0.22
Dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase promoters were not affected by butyrate treatment.
Neg (not) Regulation (affected) of phenylethanolamine N-methyltransferase associated with dopamine
7) Confidence 0.32 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12508089 Disease Relevance 0.08 Pain Relevance 0.25
We have demonstrated that there are differential changes in the levels of tyrosine hydroxylase (TH), phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (Pro Enk A) mRNA in the fetal sheep adrenal during late gestation.
Regulation (changes) of phenylethanolamine N-methyltransferase
8) Confidence 0.27 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648889 Disease Relevance 0 Pain Relevance 0
Elevating effects of all three drugs on PNMT activity in the NPA may be due to decreased baroreceptor afferent impulses to the nucleus after a fall in blood pressure.
Regulation (effects) of PNMT in blood associated with pressure volume 2 under development
9) Confidence 0.26 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.28 Pain Relevance 0.45
Prolonged morphine treatment did not alter the PNMT activity in brain regions (A1/C1 and A2/C2 cell groups, medial basal hypothalamus, median eminence).
Neg (not) Regulation (alter) of PNMT in medial associated with morphine
10) Confidence 0.20 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2829923 Disease Relevance 0.08 Pain Relevance 0.58
Differential effects of increasing gestational age and placental restriction on tyrosine hydroxylase, phenylethanolamine N-methyltransferase, and proenkephalin A mRNA levels in the fetal sheep adrenal.
Regulation (effects) of phenylethanolamine N-methyltransferase associated with enkephalin
11) Confidence 0.19 Published 1998 Journal J. Neurochem. Section Title Doc Link 9648889 Disease Relevance 0 Pain Relevance 0.20
No immunoreactivity was found for serotonin, substance P, somatostatin, cholecystokinin-octapeptide, methionine-enkephalin, choline acetyltransferase, tyrosine hydroxylase, phenylethanolamine N-methyltransferase, NO-synthase, S-100, calbindin-D, calmodulin, or parvalbumin.
Neg (No) Regulation (immunoreactivity) of phenylethanolamine N-methyltransferase associated with somatostatin, enkephalin, cholecystokinin, serotonin and substance p
12) Confidence 0.15 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473576 Disease Relevance 0.19 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox