INT185802

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.71
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MMP7, SPP1) extracellular region (MMP7, SPP1) peptidase activity (MMP7)
cell adhesion (SPP1) proteinaceous extracellular matrix (MMP7) cytoplasm (SPP1)
Anatomy Link Frequency
epithelial cells 1
MMP7 (Homo sapiens)
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 216 99.90 Very High Very High Very High
cytokine 15 85.52 High High
antagonist 3 28.36 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 195 99.90 Very High Very High Very High
Disease 18 97.48 Very High Very High Very High
Fibrosis 27 89.68 High High
Hyperplasia 6 83.52 Quite High
Adhesions 9 80.08 Quite High
Pulmonary Disease 9 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Lung Cancer 6 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of osteopontin with MMP-7 in a weakest link model was more significant than 371 of these 400 genes.


MMP-7 Binding (interaction) of osteopontin
1) Confidence 0.33 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.36 Pain Relevance 0.18
In human IPF lungs, osteopontin colocalized with MMP-7 in alveolar epithelial cells, and application of weakest link statistical models to microarray data suggested a significant interaction between osteopontin and MMP-7.


MMP-7 Binding (interaction) of osteopontin in epithelial cells associated with fibrosis
2) Confidence 0.33 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.50 Pain Relevance 0.21
Furthermore, our results suggest that in IPF the interaction between MMP-7 and osteopontin may be involved in the relentlessly progressive nature of the disease, and highlight osteopontin as a potential target for therapeutic intervention in this incurable disease.


MMP-7 Binding (interaction) of osteopontin associated with fibrosis and disease
3) Confidence 0.33 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.84 Pain Relevance 0.28

General Comments

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