INT186160

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b, Grin1) enzyme binding (Grin1) embryo development (Grin2b)
cytoplasm (Grin1)
Grin2b (Rattus norvegicus)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 35 90.20 High High
c fibre 3 86.80 High High
Dorsal horn neuron 3 85.96 High High
Thermal hyperalgesia 8 84.88 Quite High
allodynia 14 75.84 Quite High
Kinase C 5 67.80 Quite High
Spinal cord 33 52.20 Quite High
antagonist 2 46.96 Quite Low
intrathecal 2 46.28 Quite Low
Acute pain 1 25.72 Quite Low
Disease Link Frequency Relevance Heat
Nociception 27 95.84 Very High Very High Very High
Hyperalgesia 13 84.88 Quite High
Neuropathic Pain 14 75.84 Quite High
Injury 14 52.76 Quite High
Pain 14 25.72 Quite Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presumably, the loss of NR2B subunits would prevent the remaining NR1 subunits from forming functional receptors in much the same way as siRNA to NR2B was found to suppress nociceptive behaviors by selectively reducing the amount of NR2B protein [27].
Negative_regulation (loss) of NR2B Negative_regulation (prevent) of NR1 associated with nociception
1) Confidence 0.37 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.50 Pain Relevance 0.72

General Comments

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