INT186558

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 84 97.48 Very High Very High Very High
Glutamate 3 93.36 High High
bradykinin 1 36.08 Quite Low
b2 receptor 1 24.24 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 7 97.28 Very High Very High Very High
Increased Venous Pressure Under Development 4 43.44 Quite Low
Adhesions 1 36.20 Quite Low
Nicotine Addiction 4 29.44 Quite Low
Hypertension 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Cardiovascular Disease 3 5.00 Very Low Very Low Very Low
Coronary Artery Disease 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low
Thrombosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that a genetic-mediated decreased eNOS activity may limit collateral development in patients with chronic coronary occlusions.


Negative_regulation (decreased) of Positive_regulation (mediated) of eNOS associated with coronary heart disease
1) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1239913 Disease Relevance 0.26 Pain Relevance 0.05
entails a closed feedback loop involving eNOS phosphorylation/activation, NO generation and subsequent PKG phosphorylation is a mechanism not typically associated with homologous desensitization of GPCRs in general, it is also in agreement with our previous studies demonstrating that TP?
Negative_regulation (involving) of Neg (NO) Positive_regulation (activation) of eNOS
2) Confidence 0.15 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05

General Comments

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