INT186623

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 18
Disease Relevance 12.22
Pain Relevance 6.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
dorsal root 5
oligodendrocyte 4
glial cells 1
lung 1
neurite 1
Mag (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 113 100.00 Very High Very High Very High
Demyelination 466 99.60 Very High Very High Very High
metalloproteinase 12 99.46 Very High Very High Very High
Sciatic nerve 243 98.58 Very High Very High Very High
Inflammatory response 2 96.64 Very High Very High Very High
gABA 1 96.64 Very High Very High Very High
Neuropathic pain 199 95.12 Very High Very High Very High
Inflammatory mediators 5 94.12 High High
allodynia 60 92.52 High High
Spinal cord 116 90.72 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 147 100.00 Very High Very High Very High
Injury 178 99.82 Very High Very High Very High
Demyelinating Disease 503 99.60 Very High Very High Very High
Schizophrenia 62 99.28 Very High Very High Very High
Lung Cancer 26 99.16 Very High Very High Very High
Nervous System Injury 172 98.72 Very High Very High Very High
Neurological Disease 2 96.40 Very High Very High Very High
INFLAMMATION 83 96.28 Very High Very High Very High
Multiple Sclerosis 156 95.28 Very High Very High Very High
Neuropathic Pain 283 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both signatures included a number of genes (MBP, MOBP, MAG, OLIG1, and OLIG2) previously found in glial cells, several of which have been linked to neurological diseases.
Negative_regulation (number) of MAG in glial cells associated with neurological disease
1) Confidence 0.42 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.74 Pain Relevance 0.17
Among the myelin proteins investigated, expression levels of MOG, MBP and MAG, except that of CNPase, were significantly attenuated in 6 week-old Olig1?
Negative_regulation (attenuated) of MAG
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.41 Pain Relevance 0.11
Injury-induced MAG down-regulation in the dorsal root was slightly observed at day 1 (91.1 ± 7.1%/n = 3) and day 3 (91.8 ± 6.5%/n = 3) post-injury (Figure 4c).
Negative_regulation (down) of MAG in dorsal root associated with injury
3) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 0.63 Pain Relevance 0.28
In the present study, we demonstrated that the sciatic nerve injury caused LPA1 receptor-mediated demyelination and its underlying MAG down-regulation only in the dorsal root, but not spinal nerve or sciatic nerve (Figures 1, 2, 4).
Negative_regulation (down) of MAG in dorsal root associated with demyelination, nervous system injury and sciatic nerve
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.08 Pain Relevance 0.66
Injury-induced MAG down-regulation in the dorsal root was slightly observed at day 1 (91.1 ± 7.1%/n = 3) and day 3 (91.8 ± 6.5%/n = 3) post-injury (Figure 4c).
Negative_regulation (regulation) of MAG in dorsal root associated with injury
5) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 0.63 Pain Relevance 0.28
Furthermore, metalloproteinase inhibition did not affect MAG down-regulation in the dorsal root following intrathecally administered LPA [32], which mimics the nerve injury in terms of induction of neuropathic pain and its underlying mechanisms [8].
Negative_regulation (regulation) of MAG in dorsal root associated with nervous system injury, neuropathic pain and metalloproteinase
6) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.12 Pain Relevance 0.98
Furthermore, metalloproteinase inhibition did not affect MAG down-regulation in the dorsal root following intrathecally administered LPA [32], which mimics the nerve injury in terms of induction of neuropathic pain and its underlying mechanisms [8].
Neg (not) Negative_regulation (down) of MAG in dorsal root associated with nervous system injury, neuropathic pain and metalloproteinase
7) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.12 Pain Relevance 0.95
It should be noted that myelin-associated glycoprotein (MAG) was also down-regulated, while growth associated protein 43, a marker protein for sprouting axonal growth, was up-regulated (Fujita, Ueda et al., unpublished data).
Negative_regulation (regulated) of myelin-associated glycoprotein
8) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.72 Pain Relevance 0.37
It should be noted that myelin-associated glycoprotein (MAG) was also down-regulated, while growth associated protein 43, a marker protein for sprouting axonal growth, was up-regulated (Fujita, Ueda et al., unpublished data).
Negative_regulation (regulated) of MAG
9) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.70 Pain Relevance 0.37
At present, 3 axon outgrowth inhibitors in CNS myelin—Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp)—have been well documented (Mueller et al 2005; Yamashita et al 2005; Kubo et al 2007).
Negative_regulation (inhibitors) of MAG in oligodendrocyte associated with central nervous system
10) Confidence 0.24 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.70 Pain Relevance 0.75
At present, 3 axon outgrowth inhibitors in CNS myelin—Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp)—have been well documented (Mueller et al 2005; Yamashita et al 2005; Kubo et al 2007).
Negative_regulation (inhibitors) of myelin-associated glycoprotein in oligodendrocyte associated with central nervous system
11) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.70 Pain Relevance 0.75
Specifically, microarray expression studies and single-gene quantitative RT-PCR studies indicate a down-regulation of MAG in at least some schizophrenia cohorts [32], [33] and one preliminary study suggested that levels of RTN4 mRNA are also increased in the cortex of some individuals with chronic schizophrenia [34].
Negative_regulation (regulation) of MAG in cortex associated with schizophrenia
12) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.77 Pain Relevance 0.03
Rho activation by outgrowth inhibitors such as MAG and Nogo is mediated through p75NTR, which enhances the dissociation of the Rho-guanine nucleotide dissociation inhibitor (Rho-GDI) from RhoA after stimulation by the neurite outgrowth inhibitors (Yamashita and Tohyama 2003).
Negative_regulation (inhibitors) of MAG in neurite
13) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.12 Pain Relevance 0.10
Several myelin inhibitors of axonal growth, including Nogo-66, myelin-associated glycoprotein, and oligodendrocyte-myelin glycoprotein, exert their effects through NgR.
Negative_regulation (inhibitors) of myelin-associated glycoprotein in oligodendrocyte
14) Confidence 0.14 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.41 Pain Relevance 0
Genes encoding proteins associated with myelin were decreased, including myelin associated glycoprotein (MAG), proteolipid protein (PLP1), oligodendrocyte-myelin glycoprotein (OMGP), and GABA A receptor alpha (GABRA1).
Negative_regulation (decreased) of myelin associated glycoprotein in oligodendrocyte associated with gaba
15) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.90 Pain Relevance 0.46
Cellular MAG hydrolase activity was decreased by more than 90% in extracts of Yju3p-deficient cells, indicating that Yju3p accounts for the vast majority of this activity in yeast.
Negative_regulation (decreased) of MAG
16) Confidence 0.08 Published 2010 Journal Biochimica et Biophysica Acta Section Abstract Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.04
However, Yju3p-deficient cells accumulated MAG only at low concentrations implicating that other cellular activities exist, such as acyltransferase or phosphorylation reactions, which contribute to the metabolization of MAG.
Negative_regulation (metabolization) of MAG
17) Confidence 0.07 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.13
We also found supportive, but not conclusive, evidence for a possible tumorigenic effect of GMA-SS welding fume in the lung tumor susceptible A/J mouse.
Spec (possible) Negative_regulation (effect) of GMA-SS in lung associated with lung cancer and aids-related complex
18) Confidence 0.06 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.48 Pain Relevance 0.05

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