INT186727

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.56
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
colon 2
skeletal muscle 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 88 94.56 High High
cytokine 17 92.20 High High
agonist 75 90.08 High High
Osteoarthritis 65 83.28 Quite High
tolerance 4 80.68 Quite High
Pain 4 76.64 Quite High
Crohn's disease 2 62.00 Quite High
fibrosis 7 39.12 Quite Low
Inflammatory mediators 6 38.28 Quite Low
Inflammatory response 9 33.08 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 100.00 Very High Very High Very High
Cancer 67 99.20 Very High Very High Very High
Colon Cancer 30 96.24 Very High Very High Very High
Apoptosis 27 96.04 Very High Very High Very High
Gastrointestinal Neoplasms 16 95.92 Very High Very High Very High
Airway Remodeling 2 95.28 Very High Very High Very High
INFLAMMATION 105 94.56 High High
Eosinophilia 2 91.80 High High
Pneumonia 2 91.24 High High
Disease 26 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activators or inhibitors but also in knockout mice, especially colon specific knockout of PPAR?
Negative_regulation (colon) of Localization (knockout) of PPAR in colon associated with targeted disruption
1) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.06 Pain Relevance 0.22
Nevertheless, some recent studies with the positive results on the possible application of PPAR?
Spec (possible) Negative_regulation (possible) of Localization (application) of PPAR
2) Confidence 0.31 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2770108 Disease Relevance 0.72 Pain Relevance 0.09
There is also a close relationship of PPAR?
Negative_regulation (close) of Localization (relationship) of PPAR
3) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.83 Pain Relevance 0
TCA cycle intermediates, amino acids and short-chain acylcarnitine species were reduced in skeletal muscle of PPAR?
Negative_regulation (reduced) of Localization (skeletal muscle) of PPAR in skeletal muscle
4) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.88 Pain Relevance 0.14
1p3000, containing about 3,000 base pairs of regulatory sequence of the gene encoding human PPAR?
Negative_regulation (pairs) of Localization (sequence) of PPAR
5) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.08 Pain Relevance 0.04
A recent study displayed a positive correlation between PPAR-?
Negative_regulation (positive) of Localization (correlation) of PPAR
6) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.98 Pain Relevance 0.19

General Comments

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