INT186807

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.19
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
middle ear 2
epithelial cells 2
endometrium 2
nasal epithelium 2
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 112 99.50 Very High Very High Very High
cytokine 87 99.36 Very High Very High Very High
endometriosis 63 96.76 Very High Very High Very High
Inflammatory response 6 90.28 High High
chemokine 35 68.96 Quite High
headache 3 24.12 Low Low
Antihistamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 138 99.66 Very High Very High Very High
INFLAMMATION 116 99.50 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.82 Very High Very High Very High
Colitis 1 98.40 Very High Very High Very High
Rhinitis 72 98.32 Very High Very High Very High
Diabetes Mellitus 5 98.22 Very High Very High Very High
Endometriosis (extended) 115 98.00 Very High Very High Very High
Thyroiditis 117 97.18 Very High Very High Very High
Critical Illness 111 96.40 Very High Very High Very High
Otitis Media 2 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of TLR2, TLR3 and TLR4 as a consequence of allergen exposure is in line with a previous report demonstrating an increase of TLR2 protein in chronic middle ear inflammation [26].
Positive_regulation (increased) of Gene_expression (expression) of TLR3 in middle ear associated with otitis media and inflammation
1) Confidence 0.53 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.45 Pain Relevance 0.10
For the first time, we present endometrial effluents expressing high levels of TLR3 and TLR4 proteins.
Positive_regulation (levels) of Gene_expression (expressing) of TLR3
2) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.27 Pain Relevance 0.06
Healthy and differentiated endometrium seems to require an adequate TLR3 and TLR4 expression.
Positive_regulation (require) of Gene_expression (expression) of TLR3 in endometrium
3) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.77 Pain Relevance 0.05
Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].
Positive_regulation (mediating) of Gene_expression (expression) of TLR3 in epithelial cells associated with cytokine
4) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.68 Pain Relevance 0.34
The mRNA expression of TLR3 was found to be elevated among patients with on-going symptomatic allergic rhinitis.
Positive_regulation (elevated) of Gene_expression (expression) of TLR3 associated with rhinitis
5) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.16 Pain Relevance 0.03
0.0009) and rise in TLR3, TLR4, TLR7 levels (p?
Positive_regulation (rise) of Gene_expression (levels) of TLR3
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.94 Pain Relevance 0.04
The expression of TLR3, TLR4, TLR7, TLR8 and TLR9 was significantly higher in mild cases than controls (p?
Positive_regulation (higher) of Gene_expression (expression) of TLR3
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.82 Pain Relevance 0.03
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of Gene_expression (levels) of TLR3 associated with cytokine
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.12 Pain Relevance 0.18
Previously, we reported an increased protein expression of TLR2, TLR3 and TLR4 in the nasal epithelium following allergen challenge [18].
Positive_regulation (increased) of Gene_expression (expression) of TLR3 in nasal epithelium
9) Confidence 0.23 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.38 Pain Relevance 0.07
Then, Hashimoto's thyroiditis has been grouped with insulitis and type-1 diabetes, colitis, and atherosclerosis as an autoimmune and inflammatory disease associated with TLR3/4 overexpression, which is in favor of environmental pathogens [39].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TLR3 associated with colitis, thyroiditis, inflammation, diabetes mellitus, disease and increased venous pressure under development
10) Confidence 0.16 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.61 Pain Relevance 0.16

General Comments

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