INT186980

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.34
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) DNA binding (Tert) cytoplasm (Tert)
chromosome (Tert) nucleolus (Tert) nucleus (Tert)
Anatomy Link Frequency
neuroblasts 1
Tert (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 12 72.04 Quite High
alcohol 36 71.60 Quite High
cerebral cortex 24 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chromosomal Instability 12 92.16 High High
Death 30 89.52 High High
Alcohol Addiction 6 72.04 Quite High
Apoptosis 114 21.52 Low Low
Fetal Alcohol Syndrome 36 18.24 Low Low
Neurodegenerative Disease 36 5.00 Very Low Very Low Very Low
Genomic Instability 24 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol's effect on Telomerase activity and TERT transcription
Transcription (transcription) of TERT
1) Confidence 0.34 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.34 Pain Relevance 0.11
Ethanol reduces telomerase reverse transcriptase (TERT) mRNA levels in neurosphere cultures
Transcription (levels) of TERT
2) Confidence 0.34 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Transcription (levels) of TERT
3) Confidence 0.29 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Therefore, we tested the hypothesis that ethanol targets TERT transcription in progenitor neuroblasts.
Transcription (transcription) of TERT in neuroblasts
4) Confidence 0.29 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Transcription (levels) of TERT
5) Confidence 0.28 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
The increase in TERT transcription following low doses of ethanol (120 mg/dl) was not followed by a measurable increase in telomerase activity, an unexpected observation in light of the marked induction of DNA synthesis and cell-cycle progression illustrated in Figure 2A, B.
Transcription (transcription) of TERT
6) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0

General Comments

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