INT187

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 21
Disease Relevance 0.51
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ephx1) enzyme binding (Ephx1)
Anatomy Link Frequency
liver 2
Ephx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 25 99.36 Very High Very High Very High
Morphine 20 98.48 Very High Very High Very High
dexamethasone 5 92.60 High High
diclofenac 1 82.56 Quite High
Paracetamol 12 81.52 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 89.44 High High
Injury 8 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral methadone treatment, previously shown to increase selectively epoxide hydrase activity in male Wistar rats, also failed to alter the amount of BP bound to hepatic macromolecules. 3-Methylcholanthrene (20 mg/kg per day, ip, for 2 days) administered 24 h before BP, decreased the level of binding from control by 30%.
Positive_regulation (increase) of epoxide hydrase associated with methadone
1) Confidence 0.69 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 519527 Disease Relevance 0 Pain Relevance 0.10
This study suggests that induction of mEH activity correlates with the increases in select phase II enzyme activities whether it is accompanied by P450 induction or not.
Positive_regulation (induction) of mEH
2) Confidence 0.67 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.20
Within the selective induction of phase II enzymes following treatment with dipyridyls or N-heterocyclic analogs of phenanthrene, strong correlations (r > or = 0.70) are observed between the increase of microsomal epoxide hydrolase (mEH) activity and UDP-glucuronosyltransferase (UGT) activities towards 4-nitrophenol, 1-naphthol and morphine.
Positive_regulation (increase) of mEH associated with morphine
3) Confidence 0.67 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.13
Within the selective induction of phase II enzymes following treatment with dipyridyls or N-heterocyclic analogs of phenanthrene, strong correlations (r > or = 0.70) are observed between the increase of microsomal epoxide hydrolase (mEH) activity and UDP-glucuronosyltransferase (UGT) activities towards 4-nitrophenol, 1-naphthol and morphine.
Positive_regulation (increase) of microsomal epoxide hydrolase associated with morphine
4) Confidence 0.67 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.13
Induction of rat hepatic microsomal epoxide hydrolase activity by some pyridine-containing compounds appears coordinately regulated with glucuronidation rather than oxidation enzymes.
Spec (appears) Positive_regulation (Induction) of microsomal epoxide hydrolase
5) Confidence 0.59 Published 1992 Journal Drug Metab. Dispos. Section Abstract Doc Link 1358578 Disease Relevance 0 Pain Relevance 0.08
Four diaryl compounds containing heterocyclic nitrogen atoms elevated microsomal epoxide hydrolase activity from 2- to 4-fold.
Positive_regulation (elevated) of microsomal epoxide hydrolase
6) Confidence 0.59 Published 1992 Journal Drug Metab. Dispos. Section Abstract Doc Link 1358578 Disease Relevance 0 Pain Relevance 0.07
Concomitant induction of microsomal epoxide hydrolase and UDP-glucuronosyltransferase activities by dipyridine compounds.
Positive_regulation (induction) of microsomal epoxide hydrolase
7) Confidence 0.59 Published 1992 Journal Drug Metab. Dispos. Section Title Doc Link 1358578 Disease Relevance 0 Pain Relevance 0.07
It is concluded that sex hormones play an important role in the induction of epoxide hydratase and glutathione S-transferase by methadone, but not of aryl hydrocarbon hydroxylase, at this particular dosage regime.
Positive_regulation (induction) of hydratase associated with methadone
8) Confidence 0.54 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.53
Comparisons between the responses of mEH, UGT and glutathione S-transferase (GST) activities were made. mEH activity was increased by beta-naphthoflavone, isosafrole, phenobarbital and clofibric acid.
Positive_regulation (increased) of mEH
9) Confidence 0.49 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.20
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.
Positive_regulation (induction) of microsomal epoxide hydrolase in liver
10) Confidence 0.45 Published 1996 Journal Toxicol. Lett. Section Title Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.17
Microsomal epoxide hydrolase activity towards cis-stilbene oxide was increased up to three-fold and cytosolic glutathione S-transferase activity towards 1-chloro-2, 4-dinitrobenzene reached twice the control value. 3.
Positive_regulation (increased) of Microsomal epoxide hydrolase
11) Confidence 0.45 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8498089 Disease Relevance 0 Pain Relevance 0.10
There was no correlation between microsomal epoxide hydrolase activity and cytochrome P-450 or the monooxygenase reaction (4-nitrophenol hydroxylase) preferentially induced by pyridine-containing compounds.
Positive_regulation (induced) of microsomal epoxide hydrolase
12) Confidence 0.43 Published 1992 Journal Drug Metab. Dispos. Section Abstract Doc Link 1358578 Disease Relevance 0 Pain Relevance 0.09
A similar pattern but of lesser magnitude was seen with glutathione S-transferase activity. 3,4-Benzoquinoline was the only agent to significantly increase microsomal epoxide hydrolase activity (2,3-fold).
Positive_regulation (increase) of microsomal epoxide hydrolase
13) Confidence 0.38 Published 1996 Journal J. Biochem. Toxicol. Section Abstract Doc Link 9176741 Disease Relevance 0 Pain Relevance 0.19
HCl given in the drinking water for 4 weeks increased microsomal epoxide hydratase activity in the liver of adult male Wistar rats, with no change in aryl hydrocarbon hydroxylase activity.
Positive_regulation (increased) of hydratase in liver
14) Confidence 0.36 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.43
Microsomal epoxide hydrolase activity was increased only by quinoline (2.7-fold).
Positive_regulation (increased) of Microsomal epoxide hydrolase
15) Confidence 0.35 Published 1997 Journal Chem. Biol. Interact. Section Abstract Doc Link 9134007 Disease Relevance 0 Pain Relevance 0.09
In contrast, when male rats were treated similarly, there was an increase in epoxide hydrase activity to 212% of controls with no change in aryl hydrocarbon hydroxylase activity.
Positive_regulation (increase) of epoxide hydrase
16) Confidence 0.32 Published 1977 Journal Drug Metab. Dispos. Section Abstract Doc Link 15816 Disease Relevance 0 Pain Relevance 0.22
Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydrase in Wistar rats pretreated with oral methadone hydrochloride.
Positive_regulation (Induction) of epoxide hydrase associated with methadone
17) Confidence 0.32 Published 1977 Journal Drug Metab. Dispos. Section Title Doc Link 15816 Disease Relevance 0 Pain Relevance 0.37
Treatment of rat with a single dose of ATB resulted in 2-21-fold increases in mEH mRNA levels at 24 h with an ED50 = 60 mg/kg. mEH mRNA level was elevated 9- and 21-fold at 12 and 24 h after treatment at 200 mg/kg respectively as compared with control.
Positive_regulation (elevated) of mEH
18) Confidence 0.11 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.07 Pain Relevance 0.07
Time-course studies showed that mEH, rGSTA2 and rGSTM1 mRNA levels were significantly increased at 12 and 24 h after ATB treatment, returning to control levels by 48 h.
Positive_regulation (increased) of mEH
19) Confidence 0.11 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.19 Pain Relevance 0.19
Treatment of rat with a single dose of ATB resulted in 2-21-fold increases in mEH mRNA levels at 24 h with an ED50 = 60 mg/kg. mEH mRNA level was elevated 9- and 21-fold at 12 and 24 h after treatment at 200 mg/kg respectively as compared with control.
Positive_regulation (increases) of mEH
20) Confidence 0.11 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.08 Pain Relevance 0.07

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