INT187132

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.15
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 174 98.32 Very High Very High Very High
rheumatoid arthritis 63 92.24 High High
Arthritis 10 82.36 Quite High
cytokine 5 72.72 Quite High
Inflammation 12 72.36 Quite High
psoriasis 1 70.28 Quite High
Pain 6 65.92 Quite High
methotrexate 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 11 97.60 Very High Very High Very High
Cancer 89 97.16 Very High Very High Very High
Carcinoma 8 96.84 Very High Very High Very High
Coronary Heart Disease 1 96.04 Very High Very High Very High
Rheumatoid Arthritis 63 92.24 High High
Hypertension 1 91.32 High High
Prostate Cancer 80 91.08 High High
Metastasis 44 90.32 High High
Wound Healing 4 87.36 High High
Hypercalcemia 11 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the established experimental system, the neutralization of TIMP-2 with purified IgG interfered with TIMP-2 binding to the catalytic domain of MMP9.
Negative_regulation (interfered) of MMP9 Binding (binding) of
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.63 Pain Relevance 0.30
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
Negative_regulation (regulation) of MMP-9 Binding (interaction) of
2) Confidence 0.32 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
Disruption of CD44/MMP-9 cluster formation, by over expression of soluble or truncated cell surface CD44 reduces tumor invasiveness in vivo [19].
Negative_regulation (Disruption) of MMP-9 Binding (formation) of associated with cancer
3) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.97 Pain Relevance 0.31
Sensitive fluorometric assay revealed that EC extract can specifically inhibit both MMP-2 and MMP-9 activities significantly (P<0.001) at 10 ?
Negative_regulation (inhibit) of MMP-9 Binding (activities) of
4) Confidence 0.22 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.07 Pain Relevance 0.03
Yamamoto and Takai have postulated that molecularinteraction between MMP-9 active sites and ACE inhibitors could brighten up the chances for MMP inhibitors for cardioprotection [35].
Negative_regulation (inhibitors) of MMP-9 Binding (molecularinteraction) of
5) Confidence 0.12 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.32 Pain Relevance 0.17

General Comments

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