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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 31.21
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEY1) protein binding transcription factor activity (HEY1) DNA binding (HEY1)
transcription factor binding (HEY1) cytoplasm (HEY1)
Anatomy Link Frequency
coronary artery 2
intrahepatic bile ducts 1
heart 1
HEY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 89 100.00 Very High Very High Very High
rheumatoid arthritis 846 99.52 Very High Very High Very High
cva 38 99.46 Very High Very High Very High
Arthritis 22 99.34 Very High Very High Very High
Pain 17 99.28 Very High Very High Very High
Bile 6 99.06 Very High Very High Very High
cytokine 198 97.68 Very High Very High Very High
Inflammation 134 97.28 Very High Very High Very High
Osteoarthritis 50 97.04 Very High Very High Very High
depression 21 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1152 100.00 Very High Very High Very High
Myocardial Infarction 453 100.00 Very High Very High Very High
Pulmonary Disease 177 100.00 Very High Very High Very High
Frailty 130 100.00 Very High Very High Very High
Heart Failure 124 100.00 Very High Very High Very High
Cirrhosis 34 100.00 Very High Very High Very High
Cardiovascular Disease 72 99.98 Very High Very High Very High
Diabetes Mellitus 78 99.92 Very High Very High Very High
Syndrome 1 99.88 Very High Very High Very High
Chronic Renal Failure 116 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-morbidity refers here to the presence of more than one illness impacting on the management of CHF and the patient's life.
CHF Binding (management) of associated with myocardial infarction
1) Confidence 0.32 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 0.81 Pain Relevance 0.14
Arthritis restricted patients' ability to manage CHF through exercise [21].
CHF Binding (manage) of associated with myocardial infarction and arthritis
2) Confidence 0.32 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 1.84 Pain Relevance 0.20
Chronic care management programs such as care coordination and care/case management often target people with CHF, diabetes, asthma, chronic obstructive pulmonary disease (COPD), and/or hypertension to provide more integrated and continuous care [3].
CHF Binding (people) of associated with asthma, pulmonary disease, diabetes mellitus, hypertension and myocardial infarction
3) Confidence 0.32 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 1.97 Pain Relevance 0
Co-morbidity influenced CHF management by masking CHF's early stages, causing late diagnosis [50] and complicating patients' attempts to manage their illness, in particular lifestyle changes and diet [40,48]; and increasing risks of undesired pharmacological interactions and adverse effects of medications, ACE inhibitors and beta-blockers [40].
CHF Binding (management) of associated with beta blocker and myocardial infarction
4) Confidence 0.32 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 1.10 Pain Relevance 0.18
Yu et al. [9], on the other hand, attempted an interpretation of the experience of older people with CHF using the transactional model of stress, which they summarised under three headings of 'Perceptions of the manifestation of CHF', 'Coping strategies when living with CHF', and 'Adjustments to living with CHF'.
CHF Binding (living) of associated with stress and myocardial infarction
5) Confidence 0.32 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 0.92 Pain Relevance 0
Factors associated with prevalent and incident CHF were those typically associated with CHF in the non-RA population (e.g., age, male gender, hypertension, coronary artery disease, diabetes, and smoking) while RA-related measures (patient-reported disability, pain, and RA global severity) were also associated with prevalent and incident CHF.
CHF Binding (associated) of in coronary artery associated with pain, pressure and volume under development, nicotine addiction, diabetes mellitus, cardiovascular disease, cv general 4 under development and rheumatoid arthritis
6) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.89 Pain Relevance 0.66
Indeed, physicians' predictions of survival in patients with various serious chronic conditions were often erroneous and optimistic.[17,18] Moreover, a fundamental issue affecting the prediction of survival of patients with severe to very severe COPD or CHF is the hypothetical death trajectory: a slow decline in quality of life punctuated by acute exacerbations of COPD or CHF from which patients with severe to very severe COPD or CHF will only partially recover until a final crisis occurs that cannot or will not be treated. [19-21]
CHF Binding (exacerbations) of associated with pulmonary disease, death and heart failure
7) Confidence 0.12 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.52 Pain Relevance 0
3.2 Whether and to what extent do the preferences with regard to life-sustaining treatments of patients with severe to very severe COPD differ from those of patients with end-stage CHF or CRF?
CHF Binding (differ) of associated with chronic renal failure, pulmonary disease and heart failure
8) Confidence 0.12 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.96 Pain Relevance 0
Factors associated with prevalent and incident CHF were those typically associated with CHF in the non-RA population (e.g., age, male gender, hypertension, coronary artery disease, diabetes, and smoking) while RA-related measures (patient-reported disability, pain, and RA global severity) were also associated with prevalent and incident CHF.
CHF Binding (associated) of in coronary artery associated with pain, pressure and volume under development, nicotine addiction, diabetes mellitus, cardiovascular disease, cv general 4 under development and rheumatoid arthritis
9) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.78 Pain Relevance 0.64
In the study by Nicola et al. [26], ischemic heart disease (including overt MI, silent MI, and angina) and risk factors for CVD accounted for the risk of incident CHF in RF negative, but not RF positive, RA patients.
CHF Binding (accounted) of in heart associated with cardiovascular disease, cv general 4 under development, rheumatoid arthritis and cva
10) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 3.38 Pain Relevance 0.39
Risk factors, echocardiographic predictors, and biochemical markers associated with the development of CHF: relationship to RA
CHF Binding (associated) of associated with cv general 4 under development and rheumatoid arthritis
11) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.08 Pain Relevance 0.47
[62], all recognized contributors to CHF risk.
CHF Binding (recognized) of associated with cv general 4 under development
12) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 3.05 Pain Relevance 0.58
Importantly, although any history of hypertension was strongly associated with prevalent CHF in the study by Wolfe et al. [27] (odds ratio 2.6 (95% CI 2.1–3.2)), Nicola et al. [26] found no association between hypertension and risk of incident CHF in RA patients followed for a median of 11.8 years.
CHF Binding (associated) of associated with pressure and volume under development, cv general 4 under development and rheumatoid arthritis
13) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.38 Pain Relevance 0.51
The absence of frank cystic dilatation of bile ducts on Colangio-MRI excluded Caroli's disease (a congenital disorder characterized by cystic dilatation of intrahepatic bile ducts without CHF) and Caroli's syndrome (the association of CHF and macroscopic liver cysts in continuity with the bile ducts).
CHF Binding (association) of in intrahepatic bile ducts associated with fibrosis, bile, syndrome, caroli's disease, cyst, disease and "congenital, hereditary, and neonatal diseases and abnormalities"
14) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2861643 Disease Relevance 2.90 Pain Relevance 0.65
Treatment with Bisoprolol evidently ameliorates the impairment of endothelial responsiveness associated with CHF.
CHF Binding (associated) of associated with frailty
15) Confidence 0.02 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 1.11 Pain Relevance 0.04
CHF compared to HC
CHF Binding (compared) of associated with frailty
16) Confidence 0.02 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0.53 Pain Relevance 0
The first five exons encode the extracellular region that embraces the high EPO affinity of A, B, D helix site-1 and the low Epo affinity of A, C helix site-2 interactions, with 7 beta-strand bipartite binding sites in appositioned EPOR dimmers.
D helix site-1 Binding (interactions) of
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.08

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