INT187355

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.47
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnn1) plasma membrane (Kcnn1) cytoplasm (Kcnn1)
Anatomy Link Frequency
neurons 2
pyramidal cells 1
pyramidal neurons 1
nervous system 1
Kcnn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 82 98.72 Very High Very High Very High
amygdala 22 96.88 Very High Very High Very High
Limbic system 11 96.80 Very High Very High Very High
midbrain 20 95.04 Very High Very High Very High
Glutamate receptor 8 94.12 High High
Action potential 82 82.96 Quite High
potassium channel 15 82.40 Quite High
Neuronal excitability 17 71.52 Quite High
fluoxetine 5 63.88 Quite High
tricyclic antidepressant 4 63.00 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 73 98.92 Very High Very High Very High
Congenital Anomalies 13 97.84 Very High Very High Very High
Targeted Disruption 13 91.96 High High
Cognitive Disorder 7 84.64 Quite High
Appetite Loss 13 73.56 Quite High
Syndrome 8 70.60 Quite High
Disease 37 66.12 Quite High
Psychosis 5 65.24 Quite High
Phobia 4 50.00 Quite Low
Cardiovascular Disorder Under Development 3 36.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization and immunohistochemistry studies on brain tissue from adult rat and mouse have shown further that the SK1, SK2 and SK3 channel subunits have partially overlapping but clearly distinct distribution patterns, with SK1 and SK2 frequently expressed in the same neurons, and SK3 presenting a complementary distribution [32, 34–36].
Gene_expression (expressed) of SK1 in neurons
1) Confidence 0.28 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.07
Detection of RNA by Northern analysis, in situ hybridization or RT-PCR analysis and protein by immunohistochemistry have revealed that SK1, SK2, and SK3 channels are expressed in the central (CNS) and peripheral (PNS) nervous system [18, 31–38], while IK seems not to be present in central neurons, but is expressed in blood and epithelial cells [19–21, 39], and in peripheral sensory, sympathetic and enteric neurons [37, 38, 40–43].
Gene_expression (expressed) of SK1 in nervous system
2) Confidence 0.28 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.04
Pyramidal neurons in the neocortex and in the hippocampal formation display high levels of SK1 and SK2 mRNA [32, 83] and protein [35, 36], while neurons in the basolateral amygdala express all three SK channel subunits [32, 36].
Gene_expression (levels) of SK1 in neurons associated with pyramidal cell and amygdala
3) Confidence 0.28 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.07 Pain Relevance 0.33
Overexpression of SK1 and SK2 subunits, as well as the application of 1-EBIO, lead to a selective enhancement of the apamin-sensitive IAHP [93, 94], while this current is strongly reduced in layer 5 pyramidal neurons from transgenic mice expressing a truncated form of the SK3 subunit that acts in a dominant negative fashion and suppresses the expression of all SK and IK channels [94].
Gene_expression (Overexpression) of SK1 in pyramidal neurons associated with targeted disruption and pyramidal cell
4) Confidence 0.21 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.09 Pain Relevance 0.25
Of the three SK channels, SK1 and SK2 are predominantly expressed in the nervous system, in cortical pyramidal cells; [37] the basal ganglia and limbic system; [26,38,39] dopaminergic (DA) midbrain neurons; [40] and supraoptic neurosecretory cells [41].
Gene_expression (expressed) of SK1 in pyramidal cells associated with pyramidal cell, midbrain and limbic system
5) Confidence 0.21 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 1.31 Pain Relevance 0.17

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