INT187723

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.29
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
chondrocytes 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 98.70 Very High Very High Very High
Inflammation 18 34.00 Quite Low
antagonist 44 5.00 Very Low Very Low Very Low
agonist 34 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 117 100.00 Very High Very High Very High
Osteoarthritis 54 98.70 Very High Very High Very High
Body Weight 4 95.20 Very High Very High Very High
Stress 10 90.44 High High
Hyperplasia 11 89.76 High High
Reprotox - General 3 38 50.00 Quite Low
Death 41 47.44 Quite Low
Breast Cancer 5 38.20 Quite Low
Cancer 4 34.40 Quite Low
INFLAMMATION 19 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a defect in leptin action on body weight homeostasis has been reported for obese individuals despite high serum leptin concentrations, the current study was undertaken to determine whether chondrocytes from obese OA patients that are exposed to elevated leptin levels, exhibit an altered response to leptin.
Spec (whether) Regulation (altered) of Spec (whether) Positive_regulation (response) of leptin in chondrocytes associated with body weight, obesity and osteoarthritis
1) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.49 Pain Relevance 0.13
In ddition, we think that, reducing estrogen levels achieved during induction of ovulation by using aromatase inhibitors may prevent the significant increase in leptin concentrations avoiding its possible deleterious effects on the outcome of treatment as explained above.
Spec (possible) Regulation (effects) of Positive_regulation (increase) of leptin
2) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.06 Pain Relevance 0
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (regulatory) of Positive_regulation (gene) of leptin associated with obesity
3) Confidence 0.10 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0
However, important central regulatory proteins such as the obesity gene leptin or PPAR-?
Regulation (important) of Positive_regulation (gene) of leptin associated with obesity
4) Confidence 0.10 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.37 Pain Relevance 0

General Comments

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