INT187836

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 18.08
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
cleavage 2
neurons 1
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 61 98.72 Very High Very High Very High
cINOD 39 97.56 Very High Very High Very High
Inflammation 389 96.48 Very High Very High Very High
Multiple sclerosis 38 96.36 Very High Very High Very High
metalloproteinase 6 94.80 High High
antagonist 23 89.56 High High
Arthritis 14 88.44 High High
anakinra 5 88.40 High High
ischemia 33 88.16 High High
rheumatoid arthritis 17 86.44 High High
Disease Link Frequency Relevance Heat
Cancer 253 100.00 Very High Very High Very High
Death 112 100.00 Very High Very High Very High
Necrosis 48 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 329 99.76 Very High Very High Very High
Apoptosis 280 98.80 Very High Very High Very High
Colon Cancer 8 98.72 Very High Very High Very High
Adhesions 6 98.12 Very High Very High Very High
Colitis 23 97.64 Very High Very High Very High
Syndrome 66 97.28 Very High Very High Very High
Lymphedema 45 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular basis of intracellular retention of TRAPS-associated mutants appears to be misfolding – based on the findings that the mutant receptors fail to bind TNF, they do not make normal preligand assembly domain-dependent interactions with wild-type TNFR1, and, due to aberrant intermolecular disulphide bonds, can form high-order oligomers [56].
TNFR1 Binding (interactions) of associated with tumor necrosis factor receptor-associated periodic syndrome
1) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.68 Pain Relevance 0.03
Mutations in TNFR1 associated with TRAPS
TNFR1 Binding (associated) of associated with tumor necrosis factor receptor-associated periodic syndrome
2) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 1.43 Pain Relevance 0.35
TNF binding studies in cells and in vitro have demonstrated that the TRAPS-associated mutant TNFR1 is unable to bind to TNF.
TNFR1 Neg (unable) Binding (bind) of associated with tumor necrosis factor receptor-associated periodic syndrome
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.88 Pain Relevance 0.07
Several metalloproteases have been implicated in the cleavage of membrane-bound TNFR1 [54].
TNFR1 Binding (bound) of in cleavage
4) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.73 Pain Relevance 0.17
A third hypothesis is that TNFR1 mutations in TRAPS cause impaired cleavage of membrane-bound TNFR1, leading to reduced serum levels of soluble TNFR1.
TNFR1 Binding (bound) of in cleavage associated with tumor necrosis factor receptor-associated periodic syndrome
5) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.46 Pain Relevance 0.06
There was an increase in the percentage of neurons showing dual staining for TNFR1 and TRPV1 after treatment with capsaicin or resiniferatoxin.
TNFR1 Binding (staining) of in neurons associated with qutenza
6) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.32 Pain Relevance 0.82
Whereas Sag exposure did not induce alterations in the expression of Bcl-2, TRAIL or TNFR1, interaction of Sags with the cognate V?
TNFR1 Binding (interaction) of
7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.04 Pain Relevance 0
TNFRSF1A, has been associated with the acute-phase process [41].
TNFRSF1A Binding (associated) of
8) Confidence 0.31 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.12 Pain Relevance 0.07
Absence of TNFR1 was associated with decreased levels of secreted TNF-?
TNFR1 Binding (associated) of
9) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 1.07 Pain Relevance 0.48
Logically, based upon promising results in these animal models, lenercept, a dimeric TNFR1 receptor extracellular domain fused to a human IgG1heavy chain fragment, was evaluated in MS patients.
TNFR1 Binding (dimeric) of associated with multiple sclerosis
10) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.46 Pain Relevance 0.43
TNFR2 can promote TNFR1 signaling by enhancing the association between solTNF and TNFR1 via a ligand passing mechanism, and it has been suggested that this ligand passing is the primary contribution of TNFR2 to TNF-mediated signaling in contrast to direct signaling pathway activation through adaptor protein association with the intracellular domain of TNFR2 [44].
TNFR1 Binding (association) of
11) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.31 Pain Relevance 0.11
One involves the interaction of a death receptor such as the tumor necrosis factor receptor-1 (TNFR1) or the Fas receptor with its ligand and the second pathway depends on the participation of mitochondria.
TNFR1 Binding (interaction) of associated with necrosis, cancer and death
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.84 Pain Relevance 0
Both forms of TNF function by binding to one of two receptors, TNFR1 (TNFRp55) and TNFR2 (TNFRp75) [13].
TNFR1 Binding (binding) of
13) Confidence 0.24 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.13 Pain Relevance 0.18
-mediated signaling is TNFR1 and TRADD, a TNF receptor adaptor protein that allows for NF-?
TNFR1 Binding (is) of
14) Confidence 0.23 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.68 Pain Relevance 0.28
aggregates into trimolecular complexes, which bind and activate the TNF receptors, TNF receptor type 1(TNFR1) and TNF receptor type 2 (TNFR2).
TNFR1 Binding (bind) of
15) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.57 Pain Relevance 0.23
The best-investigated downstream signalling pathways of apoptosis have been described as being predominantly caspase-dependent, following either the extrinsic receptor-mediated activation of caspase-3/7 via binding to members of the tumor necrosis factor receptor (TNFR) superfamily (for example, Fas receptor [CD95] and TNFR-I [CD120?])
TNFR-I Binding (binding) of associated with necrosis, cancer and apoptosis
16) Confidence 0.19 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.45 Pain Relevance 0.11
, TNFR1 rapidly associates with lipid rafts where it complexes with TNF-?
TNFR1 Binding (associates) of
17) Confidence 0.15 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.45 Pain Relevance 0.15
expression (P<0.5), while treatment with sTNF-R1 reduced TNF-?
sTNF-R1 Binding (treatment) of
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.47 Pain Relevance 0.56
interacts with TNF-R1 in an autocrine way, creating an essential
TNF-R1 Binding (interacts) of
19) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.99 Pain Relevance 0.25

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