INT188123

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.75
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc9a1) transcription factor binding (Slc9a1) transmembrane transport (Slc9a1)
Anatomy Link Frequency
brain 4
astrocytes 1
barrel cortex 1
Slc9a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 163 99.96 Very High Very High Very High
long-term potentiation 48 91.36 High High
Pyramidal cell 44 84.60 Quite High
Neurotransmitter 6 79.36 Quite High
ischemia 16 78.56 Quite High
antagonist 5 74.40 Quite High
cva 12 73.84 Quite High
Inflammation 45 70.04 Quite High
nMDA receptor 2 67.40 Quite High
Serotonin 1 58.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 258 99.98 Very High Very High Very High
Neuroblastoma 12 99.72 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 56 99.66 Very High Very High Very High
Hypoxia 24 98.60 Very High Very High Very High
Cognitive Disorder 108 97.64 Very High Very High Very High
Alzheimer's Dementia 438 96.96 Very High Very High Very High
Acidosis 12 90.72 High High
Amyloid Plaque 80 81.20 Quite High
Cv General 4 Under Development 8 78.56 Quite High
Pressure And Volume Under Development 40 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
New lines of transgenic mice were developed for this study that express high levels of APPswe/ind under the control of a tetracycline-responsive promoter.
Gene_expression (express) of swe associated with targeted disruption
1) Confidence 0.75 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.83 Pain Relevance 0.03
in the brains of each group to determine whether any change in the amount or solubility of peptide occurred while APPswe/ind expression was suppressed.
Gene_expression (expression) of swe in brains
2) Confidence 0.75 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.08 Pain Relevance 0
The PCR product was subcloned into either pcDNA3.1 zip-venus1 or pcDNA3.1 venus2 vectors using NheI-ClaI/BstBI as the restriction sites. ?
Gene_expression (using) of NheI
3) Confidence 0.65 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
After initial screening of founders, we identified four lines of tet-APPswe/ind mice that produced very high levels of transgene product in offspring coexpressing tTA (Figures 1 and Figure S1).
Gene_expression (produced) of swe
4) Confidence 0.58 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.46 Pain Relevance 0
Transgenic expression of APPswe/ind and consequent overproduction of A?
Gene_expression (expression) of swe associated with targeted disruption
5) Confidence 0.58 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.88 Pain Relevance 0.04
We are currently working to determine whether hyperactivity correlates with expression of the APPswe/ind holoprotein or its proteolytic derivatives.
Gene_expression (expression) of swe associated with attention deficit hyperactivity disorder
6) Confidence 0.58 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.96 Pain Relevance 0
We therefore examined NHE1 expression levels in astrocytes of fimbria hippocampus, an area enriched with GFAP positive astrocytes.
Spec (examined) Gene_expression (expression) of NHE1 in astrocytes associated with hippocampus
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.37 Pain Relevance 0.11
We found significantly increased NHE1 expression levels in male M5R?
Gene_expression (expression) of NHE1
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.68 Pain Relevance 0.08
GFAP expression levels were strikingly correlated with NHE1 expression levels in astrocytes, probably as a consequence of the hypoxic state of the brain of male M5R?
Gene_expression (expression) of NHE1 in brain associated with hypoxia
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.63 Pain Relevance 0.12
GFAP expression levels were strikingly correlated with NHE1 expression levels in astrocytes, probably as a consequence of the hypoxic state of the brain of male M5R?
Gene_expression (expression) of NHE1 in brain associated with hypoxia
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.56 Pain Relevance 0.12
Therefore, similar to spatial and context learning in the hippocampus, SWE produces NMDAR-independent plasticity in the barrel cortex.
Gene_expression (produces) of SWE in barrel cortex associated with hippocampus
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.08 Pain Relevance 0.27
in three extracellular systems, namely: (1) the conditioned media of cultured human Swedish mutant (Swe)APP-transfected mouse neuroblastoma cells, (2) the releasate of cortical synaptoneurosomes isolated from TgCRND8 (Swe/Indiana APP) transgenic mice, and (3) the interstitial fluid from the brains of freely moving Tg2576 SweAPP transgenic mice.


Gene_expression (transfected) of Swe in brains associated with targeted disruption and neuroblastoma
12) Confidence 0.17 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.63 Pain Relevance 0.10
In APPSwe,Ind mice bearing the Indiana (Ind) in addition to the Swedish (Swe) APP mutation of Tg2576 mice, rosiglitazone restored performance in the object recognition and Morris water maze memory tests (Escribano et al., 2010).
Gene_expression (mutation) of Swe associated with cognitive disorder
13) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.59 Pain Relevance 0.04

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