INT188204

Context Info Confidence 0.28 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.54 Pain Relevance 0.34

nucleoplasm (STAT3) aging (IL6) DNA binding (STAT3) cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)

IL6 (Homo sapiens) STAT3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 118 86.36 agonist 2 74.80 Inflammation 26 50.00 Inflammatory mediators 16 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Carcinoma 32 97.72 Lung Cancer 32 80.48 INFLAMMATION 42 50.00 Small Cell Lung Carcinoma 2 20.72 Malignant Neoplastic Disease 8 19.28 Metaplasia 16 5.00 Cancer 12 5.00 Cleidocranial Dysplasia 8 5.00 Leukemia 8 5.00 Carcinoma In Situ 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In carcinoma cell lines, the major trends included a strong STAT3 activation by LIF (ADLC, H125), an increased (ADLC, H23) or decreased STAT3 activation by IL-6 (H125, H324), a decreased ERK activation by EGF (H522), and a treatment-independent, constitutive activation of the ERK pathway (H23).

Negative_regulation (decreased) of IL-6 Positive_regulation (activation) of STAT3 associated with carcinoma

1) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.17

In carcinoma cell lines, the major trends included a strong STAT3 activation by LIF (ADLC, H125), an increased (ADLC, H23) or decreased STAT3 activation by IL-6 (H125, H324), a decreased ERK activation by EGF (H522), and a treatment-independent, constitutive activation of the ERK pathway (H23).

Negative_regulation (decreased) of IL-6 Positive_regulation (activation) of STAT3 associated with carcinoma

2) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.17

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