INT188216

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LIF) extracellular region (LIF)
LIF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 78.96 Quite High
Inflammation 26 75.00 Quite High
Inflammatory mediators 16 44.04 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 32 99.96 Very High Very High Very High
Metaplasia 16 99.64 Very High Very High Very High
Lung Cancer 32 92.40 High High
Leukemia 8 82.84 Quite High
Cancer 12 79.96 Quite High
INFLAMMATION 42 75.00 Quite High
Cleidocranial Dysplasia 8 15.12 Low Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Carcinoma In Situ 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In preneoplastic cells, the aberrant signaling that was detected most frequently was an elevated activation of ERK, a reduced or increased IL-6 and EGF response, and an increased LIF response.
Positive_regulation (increased) of Regulation (response) of LIF
1) Confidence 0.39 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.52 Pain Relevance 0.13
The pair-wise comparison also revealed that 5/23 of the abnormal cases (4 metaplasia and 1 carcinoma) had a LIF response detectable by the activation of ERK and STAT3 (Fig. 3, Fig. 4B,D,G and 4H).
Positive_regulation (had) of Regulation (response) of LIF associated with metaplasia and carcinoma
2) Confidence 0.34 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.62 Pain Relevance 0.04

General Comments

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