INT188305

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
basement membranes 3
Col4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 173 98.94 Very High Very High Very High
fibrosis 70 86.88 High High
Inflammation 28 76.52 Quite High
antagonist 1 73.52 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 1 95.80 Very High Very High Very High
Pulmonary Hypertension 35 94.64 High High
Pulmonary Disease 2 90.00 High High
Pulmonary Fibrosis 28 87.68 High High
Fibrosis 44 79.88 Quite High
INFLAMMATION 27 76.52 Quite High
Cirrhosis 30 76.16 Quite High
Injury 19 75.92 Quite High
Disease 6 70.72 Quite High
Chronic Disease 1 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Matrix metalloproteinase (MMP) is a group of Zn-dependent proteinases activated by proteolytic removal of their amino terminal, and their actions are inhibited by specific inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP).2 MMP-2 and MMP-9 are designated as 72-kDa gelatinase A and 92-kDa gelatinase B, respectively, and well known by their ability of degrading collagen type IV, the major constituent of the basement membrane.
Protein_catabolism (degrading) of collagen type IV in basement membrane associated with metalloproteinase
1) Confidence 0.12 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.80 Pain Relevance 0.67
Gelatinase A, MMP-2, can degrade denatured interstitial collagens (gelatins), type V collagen, and intact type IV collagen, which are the major components of basement membranes (4, 6).
Protein_catabolism (degrade) of type IV collagen in basement membranes
2) Confidence 0.11 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.98 Pain Relevance 0.48
Of the MMPs, expression of MMP 2 and MMP 9 in particular, which degrade type IV collagen of basement membranes, are increased in the pulmonary vascular bed, during both monocrotaline (MCT) and hypoxia-induced experimental PAH [5].
Protein_catabolism (degrade) of type IV collagen in basement membranes associated with pulmonary hypertension, hypoxia and metalloproteinase
3) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.68 Pain Relevance 0.27

General Comments

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