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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
thymus 1
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 99.22 Very High Very High Very High
Inflammation 80 98.44 Very High Very High Very High
cytokine 35 92.92 High High
interstitial cystitis 3 80.00 Quite High
Central nervous system 28 76.16 Quite High
addiction 1 54.16 Quite High
palliative 3 50.00 Quite Low
tolerance 6 33.88 Quite Low
Multiple sclerosis 158 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 94 98.44 Very High Very High Very High
Renal Disease 1 97.92 Very High Very High Very High
Diabetes Mellitus 4 96.72 Very High Very High Very High
Aging 1 94.40 High High
Cancer 35 94.00 High High
Stress 12 89.20 High High
Autoimmune Disease 46 88.12 High High
Mucositis 74 83.04 Quite High
Interstitial Cystitis 3 80.00 Quite High
Repression 9 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-adrenergic) and hormonal receptors (e.g. glucocorticoids, ACTH, opioid), whose transmembrane signaling could alter FoxP3, and SOCS and the associated signaling network.
Regulation (alter) of FoxP3 associated with opioid
1) Confidence 0.18 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.52 Pain Relevance 0.18
FoxP3 is a potential target for treatment of experimental chronic inflammatory renal disease [86] and type I diabetes [87].
Regulation (target) of FoxP3 associated with inflammation, diabetes mellitus and renal disease
2) Confidence 0.16 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.85 Pain Relevance 0.16
Forkhead box P3- (Foxp3-) dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1 [113]. miR-155-deficient mice have reduced numbers of Tregs, both in the thymus and periphery, due to impaired development.
Regulation (regulation) of Foxp3 in thymus
3) Confidence 0.12 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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