INT18871

Context Info Confidence 0.43 First Reported 1980 Last Reported 2010 Negated 5 Speculated 0 Reported most in Body Documents 18 Total Number 18 Disease Relevance 6.49 Pain Relevance 2.60

Anatomy Link Frequency spinal cord 3 PSP 2 Heart 2 pancreas 1 lungs 1 Asap1 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 11 99.84 anesthesia 17 99.30 Spinal cord 28 98.84 Chronic pancreatitis 4 97.08 headache 1 97.08 ketamine 1 90.20 antagonist 2 85.48 Inflammation 4 84.44 Deafferentation 3 77.92 agonist 2 75.00

Disease Link Frequency Relevance Heat Pancreatitis 24 100.00 Hepatotoxicity 6 99.04 Stress 4 98.60 Dizziness 1 98.00 Vomiting 1 97.40 Headache 1 97.08 Weight Loss 4 95.76 Pressure And Volume Under Development 8 95.68 Ganglion Cysts 3 93.68 Pressure Volume 2 Under Development 1 92.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results suggest the roles of GSH and N-acetylation of PAP to APAP in PAP-induced hepatotoxicity.

Regulation (roles) of PAP associated with paracetamol and hepatotoxicity

1) Confidence 0.43 Published 2001 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 11170313 Disease Relevance 0.53 Pain Relevance 0.76

These data indicate that PAP during occlusion should be monitored and/or controlled because it is a critical variable in the determination of outcome in this model of spinal cord ischemia.

Regulation (controlled) of PAP in spinal cord

2) Confidence 0.42 Published 1996 Journal Stroke Section Body Doc Link 8841344 Disease Relevance 0 Pain Relevance 0

RESULTS: Before exposure to the anesthetics, PAP increased by 8.6 +/- 1.9 cmH2O for all lungs within 4 min of hypoxia (control PAP for all lungs 19.6 +/- 2.5 cmH2O).

Regulation (control) of PAP in lungs

3) Confidence 0.38 Published 1995 Journal Anesthesiology Section Body Doc Link 7661356 Disease Relevance 0 Pain Relevance 0

Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.

Regulation (Regulation) of PAP in pancreas associated with pancreatitis

4) Confidence 0.26 Published 1996 Journal Clin. Sci. Section Title Doc Link 8795446 Disease Relevance 1.23 Pain Relevance 0.11

In a survey study, spinal cord ischemia was induced in single animals at intervals of 6, 10, 15, 30, or 40 minutes with PAP controlled at 40, 60, 80, and 110 to 120 mm Hg.

Regulation (controlled) of PAP in spinal cord

5) Confidence 0.25 Published 1996 Journal Stroke Section Body Doc Link 8841344 Disease Relevance 0 Pain Relevance 0

In a second series, ischemia was induced in groups of animals for 0, 6, 8, 10, and 12 minutes with PAP controlled at 40 mm Hg.

Regulation (controlled) of PAP

6) Confidence 0.25 Published 1996 Journal Stroke Section Body Doc Link 8841344 Disease Relevance 0 Pain Relevance 0

These results support our concept that PSP/reg and PAP are coordinately regulated SSP.

Regulation (regulated) of PAP in PSP

7) Confidence 0.25 Published 2004 Journal J. Surg. Res. Section Body Doc Link 15100001 Disease Relevance 0.26 Pain Relevance 0

Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis.

Regulation (regulation) of PAP in PSP associated with stress and chronic pancreatitis

8) Confidence 0.25 Published 2004 Journal J. Surg. Res. Section Title Doc Link 15100001 Disease Relevance 0.29 Pain Relevance 0.22

However, we were unable to detect PAP immunoreactivity in sections from rat DRG or spinal cord (unpublished observations).

Neg (unable) Regulation (immunoreactivity) of PAP in spinal cord associated with spinal cord

9) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.13 Pain Relevance 0.17

Intravascular volume is substituted under CVP or PAP control, and epinephrine or norepinephrine are used if necessary.

Regulation (control) of PAP

10) Confidence 0.13 Published 1993 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 8292703 Disease Relevance 1.46 Pain Relevance 0.21

Isoproterenol did not change PAP, markedly increased heart rate (162 +/- 8 to 216 +/- 11 beats/min), and resulted in significant arrhythmias.

Neg (not) Regulation (change) of PAP in heart

11) Confidence 0.13 Published 1991 Journal Crit. Care Med. Section Body Doc Link 1986891 Disease Relevance 0 Pain Relevance 0

Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.

Regulation (Regulation) of PAP in small intestine associated with pancreatitis

12) Confidence 0.09 Published 1996 Journal Clin. Sci. Section Title Doc Link 8795446 Disease Relevance 1.23 Pain Relevance 0.11

The results show that: 1 Anesthesia with sodium pentobarbital did not affect PAP for a given level of FIO2 : changes in PAP caused by modifications of FIO2 were not affected by anesthesia.

Neg (not) Regulation (affect) of PAP associated with anesthesia

13) Confidence 0.08 Published 1980 Journal J. Physiol. (Paris) Section Abstract Doc Link 7241393 Disease Relevance 0.09 Pain Relevance 0.22

Heart rate was independent of FIO2, but remained always higher in the anesthetized animals (Fig. 4). 2 In anesthetized animals, pulmonary de-afferentation or vagotomy affected neither PAP, nor its variations with FIO2 nor HR (Fig. 5). 3 In conscious animals, PAP and its variations with FIO2 were not affected by vagotomy (Fig. 6 and 7) or pulmonary de-afferentation (Fig. 8).

Neg (neither) Regulation (affected) of PAP in Heart

14) Confidence 0.08 Published 1980 Journal J. Physiol. (Paris) Section Abstract Doc Link 7241393 Disease Relevance 0.15 Pain Relevance 0.28

Changes in the levels of testosterone, estradiol, prostate-specific acid phosphatase (PAP), and prostate-specific antigen (PSA) in samples collected during the pretreatment period and at the time of removal of the prostate were estimated by using conventional procedures.

Regulation (Changes) of PAP

15) Confidence 0.05 Published 1998 Journal Anat. Rec. Section Abstract Doc Link 9845214 Disease Relevance 0.13 Pain Relevance 0.17

Echocardiograms showed no apparent drug-related effects on heart valves or pulmonary artery pressure (PAP).

Neg (no) Regulation (effects) of PAP in pulmonary artery

16) Confidence 0.04 Published 2009 Journal Obesity (Silver Spring) Section Abstract Doc Link 19057523 Disease Relevance 0.89 Pain Relevance 0.13

The results show that: 1 Anesthesia with sodium pentobarbital did not affect PAP for a given level of FIO2 : changes in PAP caused by modifications of FIO2 were not affected by anesthesia.

Regulation (changes) of PAP associated with anesthesia

17) Confidence 0.03 Published 1980 Journal J. Physiol. (Paris) Section Abstract Doc Link 7241393 Disease Relevance 0.09 Pain Relevance 0.23

RESULTS: Immersion in water during recovery from general anesthesia resulted in values of ABP, PAP P(endXes), deltaP(tp)max, R(L), and W that were significantly greater and values of Cdyn that were significantly less, compared with values obtained during recovery in a padded stall.

Regulation (values) of PAP

18) Confidence 0.03 Published 2001 Journal Am. J. Vet. Res. Section Body Doc Link 11763179 Disease Relevance 0 Pain Relevance 0

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