INT188734

Context Info Confidence 0.52 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0

plasma membrane (Egfr, EGFR) nucleus (Egfr, EGFR) endosome (Egfr, EGFR) cell morphogenesis (Egfr, EGFR) endoplasmic reticulum (Egfr, EGFR) Golgi apparatus (Egfr, EGFR)

Egfr (Mus musculus) EGFR (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 38.80 Central nervous system 1 5.00 cva 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Glioma 3 98.20 Disease 9 92.60 Neuroepithelial Neoplasms 9 91.12 Cancer 23 77.04 Glioblastoma 22 50.00 Necrosis 4 5.00 Pressure And Volume Under Development 2 5.00 Malignant Neoplastic Disease 2 5.00 Thrombosis 1 5.00 Central Nervous System Cancer 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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EGFR and EGFRvIII expression have been shown to increase the infiltrative and invasive properties of glioma cells [24,25], therefore, one could hypothesize that patients expressing these markers may be more likely to present with multifocal disease, ependymal dissemination, or gliomatosis cerebri and perhaps this is the confounding variable between the studies accounting for the discrepancy in prognostic impact.

EGFR Positive_regulation (increase) of Gene_expression (expression) of EGFR associated with neuroepithelial neoplasms, disease and glioma

1) Confidence 0.52 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.61 Pain Relevance 0

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