INT189171

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.88
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 4
lymphocytes 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 100 94.08 High High
Inflammation 69 77.08 Quite High
fibrosis 19 74.96 Quite High
Inflammatory response 14 62.32 Quite High
Potency 1 29.64 Quite Low
alcohol 5 22.92 Low Low
chemokine 18 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 108 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 172 98.92 Very High Very High Very High
Fever 35 97.84 Very High Very High Very High
Aging 34 97.52 Very High Very High Very High
Cirrhosis 45 96.32 Very High Very High Very High
Mycobacterial Infection 49 92.84 High High
Infection 91 92.68 High High
Alcoholic Liver Diseases 19 86.48 High High
Sprains And Strains 26 86.08 High High
Affective Disorder 1 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possibly this is caused by the cellular reaction to rapid internalization of CD4, which is induced by antibody binding but not by DARPin binding [8], [23].
Neg (not) Positive_regulation (induced) of Localization (internalization) of CD4
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.34 Pain Relevance 0
Multiparametric flow cytometry assays were performed to determine the relative importance of the subpopulations of influenza-specific CD3+CD4+ and CD3+CD8+ T cells that produce IL-2, IFN-?
Positive_regulation (specific) of Spec (determine) Localization (importance) of CD4 in T cells associated with influenza virus infection
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.75 Pain Relevance 0.05
It has been shown that CD4 localization in lipid rafts is required for p56lck activation and HIV-1 entry [15].
Positive_regulation (required) of Localization (localization) of CD4 associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.34 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.98 Pain Relevance 0
Before vaccination of these 6–35 month olds, an H1N1-specific response (data not shown) and a weak cross-reactive CD4 response against H5 (Figure 2) were detected, with both Th1 (IFN?)
Positive_regulation (response) of Localization (response) of CD4
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.09 Pain Relevance 0.08
Our patients were severely immunossuppressed (median CD4 39.5?
Positive_regulation (median) of Localization (39.5) of CD4
5) Confidence 0.20 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2929489 Disease Relevance 1.43 Pain Relevance 0.14
Decreases of CD3 and CD4 and increases of CD8 cells occur in elderly individuals.
Positive_regulation (increases) of Localization (Decreases) of CD4
6) Confidence 0.20 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.27 Pain Relevance 0.07
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Positive_regulation (exposed) of Localization (releasing) of CD4 in lymphocytes
7) Confidence 0.17 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.38 Pain Relevance 0.19
A previous study showed an increase in the percentage of CD69-expressing CD4+ and CD8+ T cells in Thai children within 72 h after fever onset [27].
Positive_regulation (increase) of Localization (percentage) of CD4 in T cells associated with fever
8) Confidence 0.13 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.63 Pain Relevance 0.26

General Comments

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