INT189750

Context Info Confidence 0.26 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.36 Pain Relevance 0.38

cytoplasm (CHKB)

Anatomy Link Frequency muscle 2 CHKB (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 47 98.84 Inflammation 8 55.68 Catecholamine 4 54.32 Action potential 11 40.08 Central nervous system 3 38.72 Peripheral nervous system 1 36.64 abdominal pain 2 20.32 Pain 1 19.64 corticosteroid 24 5.00 cytokine 8 5.00

Disease Link Frequency Relevance Heat Necrosis 3 99.90 Ectopic Pregnancy 95 99.52 Cardiovascular Disorder Under Development 17 94.52 Apoptosis 10 87.48 Muscle Disease 91 86.24 Neuropathy 80 86.08 Muscle Weakness 2 82.96 Critical Illness 21 80.48 Injury 2 73.68 Tubal Pregnancy 10 67.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ROC curves demonstrated significant discriminatory capability of increased CK for EP diagnosis, suggesting that CK concentrations could be used to predict EP.42

Negative_regulation (used) of Positive_regulation (concentrations) of CK associated with ectopic pregnancy

1) Confidence 0.26 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.10 Pain Relevance 0.03

To further verify the involvement of PKC in the Receptor Ck signaling pathway, the effect of PKC inhibitor was investigated in a situation where Receptor Ck activation was blocked.

Negative_regulation (blocked) of Positive_regulation (activation) of Ck associated with kinase c

2) Confidence 0.23 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.32

Even in patients with overt muscle necrosis, an increase in CK is often transient and can be missed.

Negative_regulation (missed) of Positive_regulation (increase) of CK in muscle associated with necrosis

3) Confidence 0.14 Published 2008 Journal Crit Care Section Body Doc Link PMC2646339 Disease Relevance 0.95 Pain Relevance 0

When all courses were taken together, an increase in ANP and CK-MB occurred after DXR.

Negative_regulation (occurred) of Positive_regulation (increase) of CK-MB

4) Confidence 0.06 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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