INT189999

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
cytoplasm (Vta1)
Anatomy Link Frequency
DA neurons 1
olfactory tubercle 1
ventral 1
Vta1 (Rattus norvegicus)
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 70 100.00 Very High Very High Very High
Ventral tegmentum 63 100.00 Very High Very High Very High
Dopamine 154 99.68 Very High Very High Very High
Central nervous system 19 92.84 High High
antagonist 17 88.12 High High
Substantia nigra 18 87.68 High High
Eae 13 87.16 High High
agonist 28 87.04 High High
analgesia 2 75.92 Quite High
ischemia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 21 100.00 Very High Very High Very High
Disease 56 97.84 Very High Very High Very High
Schizophrenia 50 97.56 Very High Very High Very High
Cognitive Disorder 11 94.68 High High
Hypertension 18 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Natriuresis 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mesocorticolimbic pathway consists of DA neurons in the VTA that project to the NAc and PFC [51].
VTA Binding (project) of PFC in DA neurons associated with nucleus accumbens, ventral tegmentum and dopamine
1) Confidence 0.08 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0.06 Pain Relevance 0.68
The mesocorticolimbic pathway, which arises in the VTA and projects to the PFC and limbic areas, such as the NAc and the olfactory tubercle, is involved in regulating motivational behavior, learning, memory and cognition.
VTA Binding (projects) of PFC in olfactory tubercle associated with nucleus accumbens, ventral tegmentum and cognitive disorder
2) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.64 Pain Relevance 0.56
This unique neuropharmacological feature appears to have therapeutic potential because based on the concept of schizophrenia pathogenesis, an imbalance of brain DA function arises from dysfunction of D1 receptors in the medial prefrontal cortex (mPFC) and hyperactivity of D2 receptors in lower structures of cortex, such as the ventral tegmental area (VTA) and nucleus accumbens (NAc).
VTA Binding (hyperactivity) of mPFC in ventral associated with nucleus accumbens, ventral tegmentum, dopamine, attention deficit hyperactivity disorder and schizophrenia
3) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.55 Pain Relevance 0.72

General Comments

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