INT19008

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2008
Negated 4
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.40
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 4
plasma 2
arcuate nucleus 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 27 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Somatostatin 25 99.96 Very High Very High Very High
Sumatriptan 20 99.16 Very High Very High Very High
agonist 27 98.74 Very High Very High Very High
opiate 6 94.96 High High
Serotonin 9 75.00 Quite High
Opioid 5 50.00 Quite Low
abdominal pain 2 25.00 Low Low
antagonist 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 3 99.96 Very High Very High Very High
Starvation 11 98.58 Very High Very High Very High
Eating Disorder 11 98.08 Very High Very High Very High
Growth Problems 4 97.40 Very High Very High Very High
Obesity 14 96.64 Very High Very High Very High
Frailty 9 96.08 Very High Very High Very High
Stress 51 91.84 High High
Syndrome 3 76.48 Quite High
Aging 34 73.60 Quite High
Polycystic Ovary Syndrome 7 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of somatostatin caused enhanced GH response to GRF and no increase in basal GH level with pre-treatment of antiserum against somatostatin.
Positive_regulation (enhanced) of Positive_regulation (response) of GRF associated with somatostatin
1) Confidence 0.49 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.48
Neither dermorphin nor 2549 released GH or augmented the GH responses of GHRP or GHRH in vitro by a direct pituitary action, while GHRH antiserum inhibited the GH response of both dermorphin and 2549 in vivo.
Neg (Neither) Positive_regulation (augmented) of Positive_regulation (responses) of GHRH in pituitary
2) Confidence 0.48 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.53
Growth hormone-releasing hormone and morphine attenuate growth hormone secretagogue-induced activation of the arcuate nucleus in the male rat.
Positive_regulation (secretagogue-induced) of Positive_regulation (activation) of Growth hormone-releasing hormone in arcuate nucleus associated with morphine
3) Confidence 0.48 Published 1999 Journal Neuroendocrinology Section Title Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.31
These findings are compatible with clonidine leading to stimulation of GH by inducing endogenous GHRH release.
Positive_regulation (stimulation) of Positive_regulation (inducing) of GHRH associated with clonidine
4) Confidence 0.47 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 1.08
On the opposite, the secretion of GH induced by amino acids or clonidine is not preceded by an elevation of plasma GHRH.
Neg (not) Positive_regulation (preceded) of Positive_regulation (elevation) of GHRH in plasma associated with clonidine
5) Confidence 0.47 Published 1986 Journal Horm. Res. Section Abstract Doc Link 3093352 Disease Relevance 0.18 Pain Relevance 0.10
L-Dopa induced a 2-fold increase in circulating GHRH 30-45 min before the elevation of GH.
Positive_regulation (increase) of Positive_regulation (circulating) of GHRH
6) Confidence 0.47 Published 1986 Journal Horm. Res. Section Abstract Doc Link 3093352 Disease Relevance 0.17 Pain Relevance 0.08
It has been recently reported that pyridostigmine (PD), an indirect cholinergic agonist, probably acting via inhibition of hypothalamic somatostatin, potentiates the GH-releasing hormone (GHRH)-induced GH rise in men, but not in women.
Positive_regulation (potentiates) of Neg (not) Positive_regulation (-induced) of GH-releasing hormone associated with somatostatin and agonist
7) Confidence 0.35 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8432781 Disease Relevance 0 Pain Relevance 0.10
It has been recently reported that pyridostigmine (PD), an indirect cholinergic agonist, probably acting via inhibition of hypothalamic somatostatin, potentiates the GH-releasing hormone (GHRH)-induced GH rise in men, but not in women.
Positive_regulation (potentiates) of Neg (not) Positive_regulation (-induced) of GHRH associated with somatostatin and agonist
8) Confidence 0.35 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8432781 Disease Relevance 0 Pain Relevance 0.10
A contribution of the pituitary leptin system for the sake of decreasing metabolic rate but, at the same time, favouring GH output during starvation would require that starvation would lead to less leptin action in somatotrophs, which in turn would lead to an increase in the sensitivity to GHRH.
Positive_regulation (lead) of Positive_regulation (increase) of GHRH in pituitary associated with starvation
9) Confidence 0.30 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.56 Pain Relevance 0
In normal children, Sumatriptan administration (3 mg, sc) resulted in an increase in basal GH levels at 30 min (7.7 +/- 1.5 micrograms/L; P < 0.05) and increased GH responses to GHRH (47.3 +/- 6.4 vs. 29.6 +/- 9.7 micrograms/L; P < 0.05).
Positive_regulation (increased) of Positive_regulation (responses) of GHRH associated with sumatriptan
10) Confidence 0.16 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.16 Pain Relevance 0.79
In normal children, Sumatriptan administration (3 mg, sc) resulted in an increase in basal GH levels at 30 min (7.7 +/- 1.5 micrograms/L; P < 0.05) and increased GH responses to GHRH (47.3 +/- 6.4 vs. 29.6 +/- 9.7 micrograms/L; P < 0.05).
Positive_regulation (increase) of Positive_regulation (responses) of GHRH associated with sumatriptan
11) Confidence 0.16 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.17 Pain Relevance 0.81
Replacement of GH or stimulation of GH secretion with GH-releasing hormone (GHRH) or other GH secretagogues (GHS) would thus seem to be an appealing option to delay the onset of frailty in older adults and to prolong the capacity for independent living; but the balance of pros and cons is not necessarily the same as in AGHD.
Positive_regulation (Replacement) of Positive_regulation (stimulation) of GHRH associated with frailty
12) Confidence 0.11 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.48 Pain Relevance 0
In normoinsulinemic patients with PCOS, the GH response to the GHRH test increased significantly after treatment, whereas the AUC-I was not affected.
Positive_regulation (increased) of Positive_regulation (response) of GHRH
13) Confidence 0.08 Published 1999 Journal Fertil. Steril. Section Body Doc Link 9935127 Disease Relevance 0 Pain Relevance 0
The growth hormone (GH) responses to GH-releasing hormone (GHRH; 1 microgram/kg BW in an i.v. bolus), clonidine (150 micrograms in a single oral dose) and insulin (0.15 IU/kg BW in an i.v. bolus) induced hypoglycemia were evaluated in 7 normal weight bulimic women with regular menstrual cycles and in 7 age- and weight-matched normal women.
Positive_regulation (responses) of Positive_regulation (induced) of GHRH associated with hypoglycemia, eating disorder and clonidine
14) Confidence 0.08 Published 1990 Journal Neuropsychobiology Section Abstract Doc Link 2126361 Disease Relevance 0.40 Pain Relevance 0.17
RESULT(S): In patients with PCOS, the administration of naltrexone increased the GH response to the GHRH test without interfering with the insulin response to the oral glucose tolerance test.
Positive_regulation (increased) of Positive_regulation (response) of GHRH
15) Confidence 0.07 Published 1999 Journal Fertil. Steril. Section Body Doc Link 9935127 Disease Relevance 0.28 Pain Relevance 0

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